Marzaioli, Alberto Maria (2015) Structure/activity evaluation of the bacterial membrane constituents involved in the immune system. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Structure/activity evaluation of the bacterial membrane constituents involved in the immune system
Creators:
CreatorsEmail
Marzaioli, Alberto Mariaalbertomaria.marzaioli@unina.it
Date: 31 March 2015
Number of Pages: 147
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Chimiche
Scuola di dottorato: Scienze chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 27
Coordinatore del Corso di dottorato:
nomeemail
Paduano, Luigiluigi.paduano@unina.it
Tutor:
nomeemail
De Castro, CristinaUNSPECIFIED
Date: 31 March 2015
Number of Pages: 147
Uncontrolled Keywords: CARBOHYDRATES, ORGANIC CHEMISTRY, NMR, GC-MS, MALDI
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 09 Apr 2015 09:15
Last Modified: 07 Oct 2015 08:29
URI: http://www.fedoa.unina.it/id/eprint/10391
DOI: 10.6092/UNINA/FEDOA/10391

Abstract

The Lipopolysaccharides (LPSs) are the major constituents of the outer membrane of Gram-negative bacteria and with capsular polysaccharides (CPSs) and peptidoglycan (PGN) are involved in the interaction with immune system receptors. The chemical characterization of these molecules is fundamental for the elucidation of correlation existing between the structure and the biological activity. The present thesis deals with the structural study of Lipopolysaccharides and Capsular polysaccharides from different Gram-negative bacteria. The last part of thesis is focused on the preparation of the building block for the synthesis of new glycoconjugates with potential activity against HIV-1.

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