Saggese, Anella (2017) Analysis of the spore structure in the model species Bacillus subtilis and Bacillus megaterium. [Tesi di dottorato]

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Item Type:	Tesi di dottorato
Lingua:	English
Title:	Analysis of the spore structure in the model species Bacillus subtilis and Bacillus megaterium
Creators:	Creators Email Saggese, Anella ornellasaggese2010@libero.it
Date:	7 April 2017
Number of Pages:	108
Institution:	Università degli Studi di Napoli Federico II
Department:	Biologia
Dottorato:	Biologia
Ciclo di dottorato:	29
Coordinatore del Corso di dottorato:	nome email Cozzolino, Salvatore salvatore.cozzolino@unina.it
Tutor:	nome email Baccigalupi, Loredana UNSPECIFIED
Date:	7 April 2017
Number of Pages:	108
Uncontrolled Keywords:	Bacillus subtilis, Bacillus megaterium, spores
Settori scientifico-disciplinari del MIUR:	Area 05 - Scienze biologiche > BIO/19 - Microbiologia generale
Date Deposited:	20 Apr 2017 11:34
Last Modified:	16 Mar 2018 13:09
URI:	http://www.fedoa.unina.it/id/eprint/11502
DOI:	10.6093/UNINA/FEDOA/11502

Abstract

In my PhD project I studied two bacteria of the same genus, Bacillus subtilis and Bacillus megaterium. These organisms are Gram-positive, spore formers and, therefore, share the ability to undergo a complex developmental cell differentiation process and produce highly resistant spores. My studies focused on the molecular characterization of the spore surface of these two bacterial species. In particular I characterized the role of three coat components, CotG, CotH and CotE in Bacillus subtilis and I identified a protein involved in the exosporium assembly in Bacillus megaterium. I also investigated on the possibility to use B. megaterium spores as a platform to display heterologous proteins with various biological activities on their surface in order to use them for biotechnological applications.

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