Aiello, Eugenio (2017) THE SAFETY ASSESSMENT OF HERBALS WITH A NEW AND ETHICAL APPROACH. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: THE SAFETY ASSESSMENT OF HERBALS WITH A NEW AND ETHICAL APPROACH
Creators:
CreatorsEmail
Aiello, Eugenioaielloeugenio@gmail.com
Date: 10 December 2017
Number of Pages: 101
Institution: Università degli Studi di Napoli Federico II
Department: dep05
Dottorato: phd071
Ciclo di dottorato: 30
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
Calignano, AntonioUNSPECIFIED
Date: 10 December 2017
Number of Pages: 101
Uncontrolled Keywords: NOEL - REGULATORY - TOXICOLOGY - SAFETY ASSESSMENT
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/01 - Botanica generale
Area 05 - Scienze biologiche > BIO/14 - Farmacologia
Date Deposited: 19 Dec 2017 12:59
Last Modified: 22 Mar 2019 10:49
URI: http://www.fedoa.unina.it/id/eprint/12161

Abstract

The increasing use of plant medicines (herbals) in Europe needs a shared methodology to determine the toxicity and the daily exposure level to these drugs. For this reason, the European regulatory agencies have undertaken a study that could meet popular uses and toxicological research in di erent countries of the Union. Here we list some examples of the most used herbal drug classes and we propose a decision-making process based on their characteristics, their content in active principles and on the basis of the present scientific pharmacological and toxicological literature. The proposed decision tree actually makes easier for the assessor to quickly and accurately evaluate the accredited indexes for risk and toxicity assessment based on the preclinical literature data and using the correct classi cation that some of them may have because they are already present in medicinal products or used as food.

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