Pinto, Brunella (2017) SECONDARY STRUCTURES OF DNA AND PNA: FROM ORDERED SUPRAMOLECULAR GQUADRUPLEXES TO PNA/DNA HETERODUPLEXES. [Tesi di dottorato]
Preview |
Text
BrunellaPinto_PhDThesis.pdf Download (10MB) | Preview |
| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | SECONDARY STRUCTURES OF DNA AND PNA: FROM ORDERED SUPRAMOLECULAR GQUADRUPLEXES TO PNA/DNA HETERODUPLEXES |
| Creators: | Creators Email Pinto, Brunella brunella.pinto87@gmail.com |
| Date: | 22 December 2017 |
| Number of Pages: | 146 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | dep19 |
| Dottorato: | phd012 |
| Ciclo di dottorato: | 30 |
| Coordinatore del Corso di dottorato: | nome email Sannia, Giovanni sannia@unina.it |
| Tutor: | nome email Piccialli, Gennaro UNSPECIFIED |
| Date: | 22 December 2017 |
| Number of Pages: | 146 |
| Keywords: | G quadrupleces peptide nucleic acids |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Date Deposited: | 15 Jan 2018 09:48 |
| Last Modified: | 18 Mar 2019 08:49 |
| URI: | http://www.fedoa.unina.it/id/eprint/12263 |
Collection description
Oligonucleotides and oligonucleotide analogues are extremely versatile molecules from a biotechnological point of view, since they could be used as scaffolds for the development of new drugs in therapeutics, but also for the development of new materials in nanotechnology. The present thesis is included in this context and it is aimed at the discovery of all potential applications of these molecules. In particular, my work is mainly focused on: ✓ The synthesis and characterization of a novel G-rich ODN sequence for the development of long G-wires; ✓ The synthesis and characterization of PNA sequences to be used in a novel approach for the treatment of Cystic Fibrosis; ✓ The synthesis and characterization of a short sequence of PNA conjugated to a novel bifunctional linker aimed at the obtainment of PNA-based quadruplex.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |
