Pinto, Brunella (2017) SECONDARY STRUCTURES OF DNA AND PNA: FROM ORDERED SUPRAMOLECULAR GQUADRUPLEXES TO PNA/DNA HETERODUPLEXES. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: SECONDARY STRUCTURES OF DNA AND PNA: FROM ORDERED SUPRAMOLECULAR GQUADRUPLEXES TO PNA/DNA HETERODUPLEXES
Creators:
CreatorsEmail
Pinto, Brunellabrunella.pinto87@gmail.com
Date: 22 December 2017
Number of Pages: 146
Institution: Università degli Studi di Napoli Federico II
Department: dep19
Dottorato: phd012
Ciclo di dottorato: 30
Coordinatore del Corso di dottorato:
nomeemail
Sannia, Giovannisannia@unina.it
Tutor:
nomeemail
Piccialli, GennaroUNSPECIFIED
Date: 22 December 2017
Number of Pages: 146
Uncontrolled Keywords: G quadrupleces peptide nucleic acids
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 15 Jan 2018 09:48
Last Modified: 18 Mar 2019 08:49
URI: http://www.fedoa.unina.it/id/eprint/12263

Abstract

Oligonucleotides and oligonucleotide analogues are extremely versatile molecules from a biotechnological point of view, since they could be used as scaffolds for the development of new drugs in therapeutics, but also for the development of new materials in nanotechnology. The present thesis is included in this context and it is aimed at the discovery of all potential applications of these molecules. In particular, my work is mainly focused on: ✓ The synthesis and characterization of a novel G-rich ODN sequence for the development of long G-wires; ✓ The synthesis and characterization of PNA sequences to be used in a novel approach for the treatment of Cystic Fibrosis; ✓ The synthesis and characterization of a short sequence of PNA conjugated to a novel bifunctional linker aimed at the obtainment of PNA-based quadruplex.

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