ALCIDI, BRUNELLA (2018) Identification and characterization of anti-caries natural compounds and their use in experimental slow release tablets as advancement of oral health strategies. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Identification and characterization of anti-caries natural compounds and their use in experimental slow release tablets as advancement of oral health strategies.
Creators:
CreatorsEmail
ALCIDI, BRUNELLAbrunella.alcidi@gmail.com
Date: June 2018
Number of Pages: 57
Institution: Università degli Studi di Napoli Federico II
Department: dep16
Dottorato: phd053
Ciclo di dottorato: 30
Coordinatore del Corso di dottorato:
nomeemail
Marone, Giannimarone@unina.iT
Tutor:
nomeemail
Ingenito, AnielloUNSPECIFIED
Date: June 2018
Number of Pages: 57
Uncontrolled Keywords: CARIES, NATURAL COMPOUNDS, MUCADHESIVE TABLETS.
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/28 - Malattie odontostomatologiche
Date Deposited: 22 Jun 2018 06:41
Last Modified: 12 Mar 2019 10:57
URI: http://www.fedoa.unina.it/id/eprint/12289

Abstract

The intent of this research program was to determine a new way in caries prevention. The score was the development of new formulation for topical administration of natural anti-caries active compounds in the oral cavity. Mucoadhesive tablets containing CPP-ACP, Stevia rebaudiana Bertoni and pomegranate peel extract, after excluding any citotossic activity, were performed .The tablets have been evaluated in terms of swelling, mucoadhesion and organoleptic characteristics. On the basis of the results obtained from this research, the usage of mucoadhesive buccal drug delivery system could be a novel route of anticaries bio-active molecules administration by offering prolonged contact at the site of administration and satisfying the compliance of the patients.

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