De Fenza, Maria (2018) Selectivity of biomolecular recognition processes: synthesis and pharmacological activity of novel biomimetic agents. [Tesi di dottorato]
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MariaDeFenza_PhDThesis_XXXIciclo.pdf Download (8MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Selectivity of biomolecular recognition processes: synthesis and pharmacological activity of novel biomimetic agents. |
| Autori: | Autore Email De Fenza, Maria maria.defenza@unina.it |
| Data: | 19 Dicembre 2018 |
| Numero di pagine: | 188 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 31 |
| Coordinatore del Corso di dottorato: | nome email Paduano, Luigi luigi.paduano@unina.it |
| Tutor: | nome email Guaragna, Annalisa [non definito] |
| Data: | 19 Dicembre 2018 |
| Numero di pagine: | 188 |
| Parole chiave: | Glycomimetics; iminosugars; rare diseases; nucleoside analogues; antiviral agents; modified oligonucleotides; preorganized nucleic acids. |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Depositato il: | 19 Gen 2019 16:24 |
| Ultima modifica: | 16 Giu 2020 10:07 |
| URI: | http://www.fedoa.unina.it/id/eprint/12711 |
Abstract
Biomimetic agents are synthetic compounds devised to resemble structures and properties of natural biomolecules with the aim to solve complex human problems. Glycomimetics, nucleoside analogues (NAs) and modified oligonucleotides (MOs) represent biomimetic agents that have found various pharmacological applications and constitute the topic of the three main sections in which this PhD thesis has been organized. The design, the synthesis and then the biological evaluation of such molecules have been undertaken; in all cases the aim was the development of new agents with targeted pharmacological activity or improved biological selectivity in several medicinal chemistry contexts.
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