Makvandi, Pooyan (2020) Polysaccaharides based systems towards regenerative medicine and drug delivery applications. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Lingua: English
Title: Polysaccaharides based systems towards regenerative medicine and drug delivery applications
Date: 2 March 2020
Number of Pages: 122
Institution: Università degli Studi di Napoli Federico II
Department: Ingegneria Chimica, dei Materiali e della Produzione Industriale
Dottorato: Ingegneria dei prodotti e dei processi industriali
Ciclo di dottorato: 32
Coordinatore del Corso di dottorato:
Borzacchiello, AssuntaUNSPECIFIED
Mensitieri, GiuseppeUNSPECIFIED
Date: 2 March 2020
Number of Pages: 122
Uncontrolled Keywords: Hyaluronic acid, regenerative medicine, Antibacterial nanocompounds, silver nanoparticles
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/05 - Scienza e tecnologia dei materiali polimerici
Area 09 - Ingegneria industriale e dell'informazione > ING-IND/22 - Scienza e tecnologia dei materiali
Date Deposited: 22 Mar 2020 22:57
Last Modified: 17 Nov 2021 10:43


Infection is a crucial and generally unsolved issue in tissue engineering applications such as in wound healing and bone regeneration. In this study, we have prepared different antibacterial platforms containing hyaluronic acid and silver nanoparticles. Silver nanoparticles (Ag NPs) were biosynthesized by a microwave-assisted green technique using corn silk extract in an organic solvent-free medium. The thermosensitive and injectable hydrogels were prepared and their potential use as wound care materials and bone regeneration were investigated. Rheological analysis demonstrated that the nanocomposites have good mechanical properties with gelation temperature close to the body temperature; hence, they can be easily administrated locally on wounded skins and bone defect. The samples exhibited antibacterial activity toward gram-positive and gram-negative bacteria. Cytotoxicity assay showed that the hydrogels have good biocompatibility. Interestingly, an in-vitro model of wound healing revealed that the nanocomposites allow faster wound closure and repair, compared to the control. Regarding the bone tissue engineering applications, mesenchymal stem cells seeded in the nanocomposite exhibited high bone differentiation which indicate that they could be a good candidate as a potential scaffold for bone tissue regeneration. In another study, we exploited the advantages of local drug delivery by developing a platform with improved efficacy. Having this in mind, we prepared hyaluronic acid-based device containing diclofenac sodium-encapsulated (2-Hydroxypropyl)-β-cyclodextrin (CD) that possess high drug loading along with prolonged release. The platform showed high mechanical properties along with low friction indications high lubricity of the platform. L929 cell morphology and viability assay showed a over the 100 % (approximately 110%) for the injectable device.


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