Cruz Maya, Iriczalli
(2020)
Preparation and Characterization of Scaffolds for Tissue Engineering.
[Tesi di dottorato]
Abstract
The main challenge of tissue engineering is to design scaffolds able to reproduce the natural environment of cells, it means, the native extracellular matrix by including morphological and biochemical cues. From the morphological point of view, natural ECM may be organized randomly or aligned or semi-aligned, meanwhile, the addition of natural polymers is able to improve the biological properties of biomaterials. In this work, it will be explored the use of electrofluidodynamic technologies (EFDTs), namely electrospinning and electrospraying for the development of bioinspired devices for the application in tissue engineering and drug delivery systems. Different strategies were developed via EFDTs by using different biomaterials such as natural proteins and created oriented fibers to improve the cell-material interaction through chemical and morphological signals.
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