Marzano, Maria (2020) DNA G Quadruplexes: from nucleic acids involved in gene control expression to highly ordered supramolecular structures. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | DNA G Quadruplexes: from nucleic acids involved in gene control expression to highly ordered supramolecular structures |
| Autori: | Autore Email Marzano, Maria maria.marzano@unina.it |
| Data: | Aprile 2020 |
| Numero di pagine: | 183 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Biologia |
| Dottorato: | Biotecnologie |
| Ciclo di dottorato: | 32 |
| Coordinatore del Corso di dottorato: | nome email Moracci, Marco marco.moracci@unina.it |
| Tutor: | nome email Piccialli, Gennaro [non definito] |
| Data: | Aprile 2020 |
| Numero di pagine: | 183 |
| Parole chiave: | G-quadruplexes; Peptide Nucleic Acids; Oligonucleotides. |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Depositato il: | 06 Apr 2020 09:27 |
| Ultima modifica: | 10 Nov 2021 10:15 |
| URI: | http://www.fedoa.unina.it/id/eprint/13053 |
Abstract
Synthetic nucleosides, nucleotides and nucleic acids are extremely versatile molecules, all from a biological, biotechnological and therapeutic point of view. In fact, by virtue of their remarkable properties, such as: higher bioavailability, affinity with target, biostability and higher resistance against nucleases degradation, they can be used as diagnostic tools, nanoprobes, biosensors, vaccines, aptamers, but also for the development of new materials in nanotechnology fields. In this contest resides my research activity dedicated to the synthesis and study of analogues ODN, with potential application properties ranging from the development of new strategies for gene regulation and recognition of specific proteins, until the construction of new scaffolds based on higher ordered supramolecular structures.
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