Marzano, Maria (2020) DNA G Quadruplexes: from nucleic acids involved in gene control expression to highly ordered supramolecular structures. [Tesi di dottorato]
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Item Type: | Tesi di dottorato |
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Resource language: | English |
Title: | DNA G Quadruplexes: from nucleic acids involved in gene control expression to highly ordered supramolecular structures |
Creators: | Creators Email Marzano, Maria maria.marzano@unina.it |
Date: | April 2020 |
Number of Pages: | 183 |
Institution: | Università degli Studi di Napoli Federico II |
Department: | Biologia |
Dottorato: | Biotecnologie |
Ciclo di dottorato: | 32 |
Coordinatore del Corso di dottorato: | nome email Moracci, Marco marco.moracci@unina.it |
Tutor: | nome email Piccialli, Gennaro UNSPECIFIED |
Date: | April 2020 |
Number of Pages: | 183 |
Keywords: | G-quadruplexes; Peptide Nucleic Acids; Oligonucleotides. |
Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
Date Deposited: | 06 Apr 2020 09:27 |
Last Modified: | 10 Nov 2021 10:15 |
URI: | http://www.fedoa.unina.it/id/eprint/13053 |
Collection description
Synthetic nucleosides, nucleotides and nucleic acids are extremely versatile molecules, all from a biological, biotechnological and therapeutic point of view. In fact, by virtue of their remarkable properties, such as: higher bioavailability, affinity with target, biostability and higher resistance against nucleases degradation, they can be used as diagnostic tools, nanoprobes, biosensors, vaccines, aptamers, but also for the development of new materials in nanotechnology fields. In this contest resides my research activity dedicated to the synthesis and study of analogues ODN, with potential application properties ranging from the development of new strategies for gene regulation and recognition of specific proteins, until the construction of new scaffolds based on higher ordered supramolecular structures.
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