Marzano, Maria (2020) DNA G Quadruplexes: from nucleic acids involved in gene control expression to highly ordered supramolecular structures. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: DNA G Quadruplexes: from nucleic acids involved in gene control expression to highly ordered supramolecular structures
Creators:
CreatorsEmail
Marzano, Mariamaria.marzano@unina.it
Date: April 2020
Number of Pages: 183
Institution: Università degli Studi di Napoli Federico II
Department: Biologia
Dottorato: Biotecnologie
Ciclo di dottorato: 32
Coordinatore del Corso di dottorato:
nomeemail
Moracci, Marcomarco.moracci@unina.it
Tutor:
nomeemail
Piccialli, GennaroUNSPECIFIED
Date: April 2020
Number of Pages: 183
Keywords: G-quadruplexes; Peptide Nucleic Acids; Oligonucleotides.
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 06 Apr 2020 09:27
Last Modified: 10 Nov 2021 10:15
URI: http://www.fedoa.unina.it/id/eprint/13053

Collection description

Synthetic nucleosides, nucleotides and nucleic acids are extremely versatile molecules, all from a biological, biotechnological and therapeutic point of view. In fact, by virtue of their remarkable properties, such as: higher bioavailability, affinity with target, biostability and higher resistance against nucleases degradation, they can be used as diagnostic tools, nanoprobes, biosensors, vaccines, aptamers, but also for the development of new materials in nanotechnology fields. In this contest resides my research activity dedicated to the synthesis and study of analogues ODN, with potential application properties ranging from the development of new strategies for gene regulation and recognition of specific proteins, until the construction of new scaffolds based on higher ordered supramolecular structures.

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