SOSA FERNANDEZ, LOREDANA MARIA (2021) Does bariatric surgery improve assisted reproductive technology outcomes in obese infertile patients? [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Does bariatric surgery improve assisted reproductive technology outcomes in obese infertile patients? |
| Autori: | Autore Email SOSA FERNANDEZ, LOREDANA MARIA loredana.sosafernandez@gmail.com |
| Data: | 10 Febbraio 2021 |
| Numero di pagine: | 34 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Scienze biomorfologiche e chirurgiche |
| Ciclo di dottorato: | 32 |
| Coordinatore del Corso di dottorato: | nome email cuocolo, alberto cuocolo@unina.it |
| Tutor: | nome email Musella, Mario [non definito] |
| Data: | 10 Febbraio 2021 |
| Numero di pagine: | 34 |
| Parole chiave: | infertility, bariatric surgery, art |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/18 - Chirurgia generale Area 06 - Scienze mediche > MED/36 - Diagnostica per immagini e radioterapia Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia |
| Depositato il: | 22 Gen 2021 11:47 |
| Ultima modifica: | 28 Ott 2021 12:42 |
| URI: | http://www.fedoa.unina.it/id/eprint/13279 |
Abstract
Weight loss in overweight and obese women has been shown to increase natural conception rates and to improve the course of pregnancy, but there are very few studies investigating the impact of weight reduction in overweight and/or obese women prior to undergoing assisted reproductive technology (ART) treatment. It is rationale to hypothesise that these benefits would also be applicable to women who conceive via ART. Additionally, it is important to highlight that one increasingly common treatment option to obtain weight loss is bariatric surgery. In this setting, the benefits of bariatric surgery in improving fertility status have been well shown in the literature. However, data regarding the safety and efficacy of bariatric surgery on in vitro fertilization outcomes are still controversial. Prompted by the before-mentioned observations, we aimed to investigate the effect of bariatric surgery on ART outcomes. To better identify the impact of bariatric surgery on male and female infertile patients, we have separately analysed data about man and women undergoing ART treatment after bariatric surgery. We registered a significant decrease in the total number of gonadotropin units required and in the length of stimulation in IVF cycle following bariatric surgery, with an increase of the number of follicles ≥15 mm,of the number of retrieved oocytes, of the number of top-quality oocytes and of the number of MII oocytes.After surgery, we have registered 10 also a better number of top-quality embryos. The results showed an impressive high incidence (58%) of infertile women who become spontaneously pregnant after surgery. Based on these results, bariatric interventions could be included in the treatment of obesity-related infertility. We found a significant increase, after bariatric surgery, in semen volume, sperm concentration, total sperm concentration, motile sperm count and sperm morphology. Pregnancy rate significantly increased after bariatric surgery.
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