Jamaledin, Rezvan (2021) Controlled release of bacteriophage from PLGA microparticles included in fully implantable bicompartmental polymeric microneedles to induce the innate and adaptive immune system response. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Controlled release of bacteriophage from PLGA microparticles included in fully implantable bicompartmental polymeric microneedles to induce the innate and adaptive immune system response |
| Creators: | Creators Email Jamaledin, Rezvan jamaledinrezvan@gmail.com |
| Date: | 12 July 2021 |
| Number of Pages: | 106 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Ingegneria Chimica, dei Materiali e della Produzione Industriale |
| Dottorato: | Ingegneria dei prodotti e dei processi industriali |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email D'Anna, Andrea UNSPECIFIED |
| Tutor: | nome email Raffaele, Vecchione UNSPECIFIED Antonio Netti, Paolo UNSPECIFIED |
| Date: | 12 July 2021 |
| Number of Pages: | 106 |
| Keywords: | PLGA microparticles, polymeric microneedles |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/05 - Scienza e tecnologia dei materiali polimerici |
| Date Deposited: | 29 Jul 2021 20:30 |
| Last Modified: | 07 Jun 2023 10:41 |
| URI: | http://www.fedoa.unina.it/id/eprint/13689 |
Collection description
The increasing demand for patient-compliance therapies in recent years has led to the development of intradermal and transdermal drug/vaccine delivery, which has several superiorities as compared to conventional methods. This research project endeavored to successfully encapsulate filamentous bacteriophage (Fd) into a Poly(lactic-co-glycolic acid)-based microparticulate system (PLGA MPs). The release profile of these microparticles suggests that they could be used to successfully induce immune and adaptive system. It was the first time that filamentous bacteriophages have been encapsulated in PLGA. The present study also devised a microneedle (MNs) system. A multi compartment microneedles (MNs) system was validated for a number of actives encapsulation (ex. laccase, collagenase) during the PhD activity and upon this optimization the system has been coupled with pillars as a strong mechanical pedestal to increase insertion ability. At the moment, in vivo intradermal delivery from MPs and MNs encapsulated bacteriophages are under investigation. Aside from the development of bacteriophage delivery systems, novel work in the application of fd-bacteriophage was completed with extremely successful results.
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