Pizzorusso, Vincenzo (2021) Relationship between explore to the environmental toxicant methylmercury and the transcriptional repressor rest in vitro model of amyotrophic lateral sclerosis. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Relationship between explore to the environmental toxicant methylmercury and the transcriptional repressor rest in vitro model of amyotrophic lateral sclerosis
Creators:
CreatorsEmail
Pizzorusso, Vincenzovpizzorusso@libero.it
Date: 22 April 2021
Number of Pages: 110
Institution: Università degli Studi di Napoli Federico II
Department: Neuroscienze e Scienze Riproduttive ed Odontostomatologiche
Dottorato: Neuroscienze
Ciclo di dottorato: 33
Coordinatore del Corso di dottorato:
nomeemail
TAGLIALATELA, MAURIZIOmaurizio.taglialatela@unina.it
Tutor:
nomeemail
FORMISANO, LUIGIUNSPECIFIED
Date: 22 April 2021
Number of Pages: 110
Keywords: METHYLMERCURY, AMYOTROPHIC LATERAL SCLEROSIS, REST.
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/14 - Farmacologia
Date Deposited: 19 Apr 2021 11:39
Last Modified: 07 Jun 2023 10:36
URI: http://www.fedoa.unina.it/id/eprint/13842

Collection description

Since MeHg exposure hastens the onset of amyotrophic lateral sclerosis-like phenotype in SOD1G93A mice activating glutamate receptors and determined neuronal cell death by increasing REST expression, we invesigated the possible role of MeHg to accelerate reduction in cell survival in NSC-34 motor neuron like cells transiently transfected whit G93A-SOD1 construct via REST up regulation. Furthermore, we studied the trascriptional activators Sp1, Sp3, CREB and JunD. Additionally, we identified the epigenetic mechanism by which MeHg regulated REST gene. Since REST overexpression in neurons determined cell death by activating necroptosis, we investigated the role of MeHg to activate necroptosis in NSC34 cells overexpressing G93A-SOD1 construct

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