ZIZOLFI, BRUNELLA (2021) ENDOMETRIOSIS AND MULTIPLE SCLEROSIS: DIFFERENT PHENOTYPES WITH COMMON AUTOIMMUNE BACKGROUND? [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | ENDOMETRIOSIS AND MULTIPLE SCLEROSIS: DIFFERENT PHENOTYPES WITH COMMON AUTOIMMUNE BACKGROUND? |
| Autori: | Autore Email ZIZOLFI, BRUNELLA brunellazizolfi@hotmail.it |
| Data: | 2021 |
| Numero di pagine: | 60 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Neuroscienze e Scienze Riproduttive ed Odontostomatologiche |
| Dottorato: | Neuroscienze |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email Taglialatela, Maurizio mtaglial@unina.it |
| Tutor: | nome email Bifulco, Giuseppe [non definito] |
| Data: | 2021 |
| Numero di pagine: | 60 |
| Parole chiave: | Endometriosis, Multiple Sclerosis |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia |
| Depositato il: | 18 Feb 2021 11:20 |
| Ultima modifica: | 07 Giu 2023 13:22 |
| URI: | http://www.fedoa.unina.it/id/eprint/14084 |
Abstract
Endometriosis (EMS) is an estrogen-dependent inflammatory disorder that mainly affects women of reproductive age. It is associated with an increased risk of developing different immune-mediated diseases, such as multiple sclerosis (MS), which represents the most common cause of neurological disability among young adults. Both EMS and MS are characterized by systemic inflammation and immune system dysregulation, potentially suggesting a pathogenetic link between these two entities. We report for the first time an italian epidemiological analysis of the prevalence of MS in patient with EMS. In accordance with our selection criteria, 9 out of 1652 patients of the endometriosis reference center of our gynecological department of the University of Naples "Federico II" presented co-diagnosis of EMS and MS (0.005%). As described in the literature, this data may be motivated by the possible greater association of pathologies that share an autoimmune alteration. From the analysis of the clinical data of the progress of the two pathologies, both were found to present themselves in a mild form: none of the patients has a high degree of neurological disability and none of the patients need surgical-pharmacological intervention for EMS. The diagnosis of EMS was found to follow that of MS in the whole patient group and in most cases, the diagnosis of EMS was fortuitous. Preliminary immunological data confirm an involvement of the immune system in the two pathologies with possible diversification of the protagonists: an increased ratio of CD4 T versus CD8 T lymphocytes, decreased level of B cells and a dysfunction of iNKT suppression was observed. This data may be the basis for possible future multicentre studies to extend the knowledge and discussion about two diseases with important social impact. Moreover, future research studies are needed to open up possibilities for new strategies for immunomodulatory intervention therapy and new possible therapeutic targets in order to treat or even prevent both EMS and MS.
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