Masselli, Raffaello (2021) Development of a new food supplement with anti-inflammatory activity for the relieve of the symptoms of benign prostate hypertrophy. [Tesi di dottorato]

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Item Type:	Tesi di dottorato
Resource language:	English
Title:	Development of a new food supplement with anti-inflammatory activity for the relieve of the symptoms of benign prostate hypertrophy
Creators:	Creators Email Masselli, Raffaello raffaello.masselli@unina.it
Date:	31 October 2021
Number of Pages:	112
Institution:	Università degli Studi di Napoli Federico II
Department:	Farmacia
Dottorato:	Scienza del farmaco
Ciclo di dottorato:	34
Coordinatore del Corso di dottorato:	nome email D'Auria, Maria Valeria madauria@unina.it
Tutor:	nome email Maria, Daglia UNSPECIFIED
Date:	31 October 2021
Number of Pages:	112
Keywords:	Prostate Epilobium In vivo In vitro Clinical Studies Benign Prostatic Hypertrophy
Settori scientifico-disciplinari del MIUR:	Area 05 - Scienze biologiche > BIO/10 - Biochimica Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 03 - Scienze chimiche > CHIM/10 - Chimica degli alimenti Area 06 - Scienze mediche > MED/24 - Urologia
Date Deposited:	20 Dec 2021 14:52
Last Modified:	28 Feb 2024 11:32
URI:	http://www.fedoa.unina.it/id/eprint/14346

Collection description

The prostate (or prostate gland) is a small, rounded organ that is part of the male genital system. Located in the pelvis, just below the bladder and in front of the rectum, this exocrine gland surrounds the upper part of the urethra. The main function of prostate is the contribution to the sperm production, as it secretes a part of the seminal fluid released during ejaculation. The prostate as an adjunct organ to the reproductive system, is susceptive to internal and external environmental factors at hormonal, biochemical, micronutrient and genetic level. Benign Prostatic Hypertrophy (BPH) is one of the most common conditions affecting men at a late age. This condition predominantly affects older men. About 75% of men over 50 year of age suffer from BPH related symptoms. Moreover, 20-30% of men above 80 years of age require surgical intervention for the management of BPH. [1], [2] From an histological point of view, the American Urological Association (AUA) defines BPH as “a disease process characterized by stromal and epithelial cell Hypertrophy begin in the periurethral zone of the prostate”. [3] The presence of BPH in older men is strongly linked to the development of lower urinary tract symptoms (LUTS), which are defined by several symptoms including urgency, nocturia, frequency, dysuria, difficulty in emptying the bladder, difficulty in initiating micturition, and weak or interrupted stream during micturition. Although some LUTS are defined as “LUTS independent of BPH”, BPH and its downstream effects lead to chronic LUTS in many men. BPH with LUTS has also been linked to erectile dysfunction (ED). [4] A wide variety of treatments are available for BPH, including pharmacological therapies, phytotherapies (alpha blockers, 5-alpha reductase inhibitors (5-ARIs), phospodiesterase-5 (PDE5) inhibitors), minimally invasive therapies and surgery. 6 The alpha blockers relax the muscles of the prostate and the bladder neck to relieve symptoms, 5-ARIs have been shown to shrink the prostate and prevent additional growth and PDE5 inhibitors improve prostate symptoms through the increase of the flow rate. [5] Nowaday, trying to relieve the symptoms of BPH, dietary supplements based on plant extracts obtained from Pygeum africanum Hook.f. and Serenoa repens (W. Bartram) Small, with peripheral antiandrogenic action, or containing Cucurbita pepo L. seed oil, that some studies indicate to be active in the prevention of BPH, are produced. Literature data show that the Epilobium angustifolium L., traditionally used in the European Countries for the treatment of BPH, whose active ingredient is oenothein B, has antioxidant and anti-inflammatory activity. Given the chemical and biological properties of E. angustifolium highlighted by the scientific community, this PhD project aims to characterize E. Angustifolium extract and test them with in vitro, in vivo, and clinical studies.

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