Barra, Teresa (2022) Enhanced drug delivery of neuroprotective peptides in the Central Nervous System. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Enhanced drug delivery of neuroprotective peptides in the Central Nervous System |
| Autori: | Autore Email Barra, Teresa teresa.barra@unina.it |
| Data: | 9 Marzo 2022 |
| Numero di pagine: | 129 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Biologia |
| Dottorato: | Biologia |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Esposito, Sergio sergio.esposito@unina.it |
| Tutor: | nome email Valiante, Salvatore [non definito] |
| Data: | 9 Marzo 2022 |
| Numero di pagine: | 129 |
| Parole chiave: | drug delivery, neuropeptides, blood-brain barrier |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/06 - Anatomia comparata e citologia |
| Depositato il: | 21 Mar 2022 19:59 |
| Ultima modifica: | 28 Feb 2024 10:25 |
| URI: | http://www.fedoa.unina.it/id/eprint/14493 |
Abstract
The blood brain barrier (BBB) is able to protect central nervous system (CNS) from external injuries avoiding the entrance of many molecules, harming substances as well therapeutic agents. It is mandatory to develop a reliable BBB model in order to study neurodegenerative disease and their possible therapeutic drugs. To better study the enhance of drug delivery in the CNS, we have used a millifluidic bioreactor consisting in a double chamber separated by a porous membrane that mimic both basolateral and apical compartment of the physiological barrier. Starting from the main component of BBB, brain endothelial cells, we have optimized for three years an in vitro fluid dynamic model adding also neural and glial cell line. Using 3D cell biostructure, we are able, to date, to mimic the physiological barrier to study the delivery of nanoparticles loaded with neuroprotective agent potentially useful for the treatment of neurodegenerative diseases such as Parkinson's disease.
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