Barra, Teresa (2022) Enhanced drug delivery of neuroprotective peptides in the Central Nervous System. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Resource language: English
Title: Enhanced drug delivery of neuroprotective peptides in the Central Nervous System
Date: 9 March 2022
Number of Pages: 129
Institution: Università degli Studi di Napoli Federico II
Department: Biologia
Dottorato: Biologia
Ciclo di dottorato: 34
Coordinatore del Corso di dottorato:
Valiante, SalvatoreUNSPECIFIED
Date: 9 March 2022
Number of Pages: 129
Keywords: drug delivery, neuropeptides, blood-brain barrier
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/06 - Anatomia comparata e citologia
Date Deposited: 21 Mar 2022 19:59
Last Modified: 28 Feb 2024 10:25

Collection description

The blood brain barrier (BBB) is able to protect central nervous system (CNS) from external injuries avoiding the entrance of many molecules, harming substances as well therapeutic agents. It is mandatory to develop a reliable BBB model in order to study neurodegenerative disease and their possible therapeutic drugs. To better study the enhance of drug delivery in the CNS, we have used a millifluidic bioreactor consisting in a double chamber separated by a porous membrane that mimic both basolateral and apical compartment of the physiological barrier. Starting from the main component of BBB, brain endothelial cells, we have optimized for three years an in vitro fluid dynamic model adding also neural and glial cell line. Using 3D cell biostructure, we are able, to date, to mimic the physiological barrier to study the delivery of nanoparticles loaded with neuroprotective agent potentially useful for the treatment of neurodegenerative diseases such as Parkinson's disease.


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