Barra, Teresa (2022) Enhanced drug delivery of neuroprotective peptides in the Central Nervous System. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Enhanced drug delivery of neuroprotective peptides in the Central Nervous System |
| Creators: | Creators Email Barra, Teresa teresa.barra@unina.it |
| Date: | 9 March 2022 |
| Number of Pages: | 129 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Biologia |
| Dottorato: | Biologia |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Esposito, Sergio sergio.esposito@unina.it |
| Tutor: | nome email Valiante, Salvatore UNSPECIFIED |
| Date: | 9 March 2022 |
| Number of Pages: | 129 |
| Keywords: | drug delivery, neuropeptides, blood-brain barrier |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/06 - Anatomia comparata e citologia |
| Date Deposited: | 21 Mar 2022 19:59 |
| Last Modified: | 28 Feb 2024 10:25 |
| URI: | http://www.fedoa.unina.it/id/eprint/14493 |
Collection description
The blood brain barrier (BBB) is able to protect central nervous system (CNS) from external injuries avoiding the entrance of many molecules, harming substances as well therapeutic agents. It is mandatory to develop a reliable BBB model in order to study neurodegenerative disease and their possible therapeutic drugs. To better study the enhance of drug delivery in the CNS, we have used a millifluidic bioreactor consisting in a double chamber separated by a porous membrane that mimic both basolateral and apical compartment of the physiological barrier. Starting from the main component of BBB, brain endothelial cells, we have optimized for three years an in vitro fluid dynamic model adding also neural and glial cell line. Using 3D cell biostructure, we are able, to date, to mimic the physiological barrier to study the delivery of nanoparticles loaded with neuroprotective agent potentially useful for the treatment of neurodegenerative diseases such as Parkinson's disease.
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