Zhang, Lingzhi (2022) Identification of Proteolysis Targeting Chimeras for TPM3-TrkA oncoprotein. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Identification of Proteolysis Targeting Chimeras for TPM3-TrkA oncoprotein
Creators:
CreatorsEmail
Zhang, Lingzhilingzhi.zhang@unina.it
Date: 9 March 2022
Number of Pages: 70
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Molecolare e Biotecnologie Mediche
Dottorato: Medicina molecolare e biotecnologie mediche
Ciclo di dottorato: 34
Coordinatore del Corso di dottorato:
nomeemail
Santoro, Massimomassimo.santoro@unina.it
Tutor:
nomeemail
Santoro, MassimoUNSPECIFIED
Date: 9 March 2022
Number of Pages: 70
Keywords: PROTAC; TRK oncogenes; pomalidomide
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/04 - Patologia generale
Date Deposited: 17 Mar 2022 15:04
Last Modified: 28 Feb 2024 14:05
URI: http://www.fedoa.unina.it/id/eprint/14528

Collection description

Tropomyosin receptor kinase A (TrkA) is a transmembrane tyrosine kinase receptor encoded by the neurotrophic tyrosine kinase receptor 1 (NTRK1) gene. NTRK1 fusions have been identified in several cancers, including colorectal, lung, and thyroid carcinomas. The aim of this study was to explore a new strategy to target TrkA fusion proteins, based on Proteolysis Targeting Chimeras (PROTACs). Our study indicated that PROTAC-mediated degradation is a novel and efficient tool to intercept Trk kinase oncogenic signaling as an innovative strategy to treat cancer.

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