Zhang, Lingzhi (2022) Identification of Proteolysis Targeting Chimeras for TPM3-TrkA oncoprotein. [Tesi di dottorato]
![[thumbnail of zhang_lingzhi_34_COMPLETO.pdf]](http://www.fedoa.unina.it/style/images/fileicons/text.png "zhang_lingzhi_34_COMPLETO.pdf") |
Text
zhang_lingzhi_34_COMPLETO.pdf Visibile a [TBR] Repository staff only Download (3MB) | Request a copy |
Preview |
Text
zhang_lingzhi_34_PARZIALE.pdf Download (4MB) | Preview |
| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Identification of Proteolysis Targeting Chimeras for TPM3-TrkA oncoprotein |
| Creators: | Creators Email Zhang, Lingzhi lingzhi.zhang@unina.it |
| Date: | 9 March 2022 |
| Number of Pages: | 70 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Medicina Molecolare e Biotecnologie Mediche |
| Dottorato: | Medicina molecolare e biotecnologie mediche |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Santoro, Massimo massimo.santoro@unina.it |
| Tutor: | nome email Santoro, Massimo UNSPECIFIED |
| Date: | 9 March 2022 |
| Number of Pages: | 70 |
| Keywords: | PROTAC; TRK oncogenes; pomalidomide |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/04 - Patologia generale |
| Date Deposited: | 17 Mar 2022 15:04 |
| Last Modified: | 28 Feb 2024 14:05 |
| URI: | http://www.fedoa.unina.it/id/eprint/14528 |
Collection description
Tropomyosin receptor kinase A (TrkA) is a transmembrane tyrosine kinase receptor encoded by the neurotrophic tyrosine kinase receptor 1 (NTRK1) gene. NTRK1 fusions have been identified in several cancers, including colorectal, lung, and thyroid carcinomas. The aim of this study was to explore a new strategy to target TrkA fusion proteins, based on Proteolysis Targeting Chimeras (PROTACs). Our study indicated that PROTAC-mediated degradation is a novel and efficient tool to intercept Trk kinase oncogenic signaling as an innovative strategy to treat cancer.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |
