Greco, Francesca (2022) DNA AND RNA OLIGONUCLEOTIDES IN THERAPY: THE PROMISING APPLICATIONS. [Tesi di dottorato]
Preview |
Text
Greco_Francesca_XXXV.pdf Download (6MB) | Preview |
| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | DNA AND RNA OLIGONUCLEOTIDES IN THERAPY: THE PROMISING APPLICATIONS |
| Creators: | Creators Email Greco, Francesca francesca.greco@unina.it |
| Date: | 9 December 2022 |
| Number of Pages: | 157 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Biologia |
| Dottorato: | Biotecnologie |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Moracci, Marco marco.moracci@unina.it |
| Tutor: | nome email Piccialli, Gennaro UNSPECIFIED |
| Date: | 9 December 2022 |
| Number of Pages: | 157 |
| Keywords: | oligonucleotide; DNA; RNA; PNA |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Date Deposited: | 22 Dec 2022 11:01 |
| Last Modified: | 09 Apr 2025 14:08 |
| URI: | http://www.fedoa.unina.it/id/eprint/14689 |
Collection description
Oligonucleotides are small molecules with easy-to-handle design and rapid production steps that have already proven their extraordinary efficacy, as witnessed by the recent development of mRNA-based vaccines against the SARS-CoV-2 virus. Natural oligonucleotides are not suitable for therapy and diagnostics due to their low thermal and enzymatic stability and modest bioavailability. Still synthetic oligonucleotide (ODN) analogous are synthesized for increasing their application. In this contest, my research studied the (ODN) relevance in diagnostics and therapy. Specifically, my research work has been focused on: o Chemical synthesis and structural and biological characterization of Peptide Nucleic Acids (PNAs) as antisense oligonucleotide and development of novel delivery platforms o Stabilization of the c-myc promoter region conformed in G-quadruplexes as promising antitumoral approach. o Realization of a new supramolecular structures formed by C-rich oligonucleotides (CROs) sequences through the introduction of non-nucleotidic linker.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |
