Armiento, Samantha (2024) Microbial polysaccharides as flexible and renewable resources for innovative applications: structural and functional studies. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Microbial polysaccharides as flexible and renewable resources for innovative applications: structural and functional studies |
| Creators: | Creators Email Armiento, Samantha samantha.armiento@unina.it |
| Date: | 11 March 2024 |
| Number of Pages: | 157 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Scienze Chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 36 |
| Coordinatore del Corso di dottorato: | nome email Lombardi, Angela angelina.lombardi@unina.it |
| Tutor: | nome email De Castro, Cristina UNSPECIFIED Molinaro, Antonio UNSPECIFIED |
| Date: | 11 March 2024 |
| Number of Pages: | 157 |
| Keywords: | polysaccharides; structural chemistry; microbiota; immunology; nutraceuticals |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Date Deposited: | 22 Mar 2024 17:28 |
| Last Modified: | 10 Mar 2026 08:01 |
| URI: | http://www.fedoa.unina.it/id/eprint/15414 |
Collection description
The term “microbiota” stands for the complex of microorganisms present in a defined environment, which coexist with their hosts without damaging them. The balance of the microbiota can play a fundamental role in host health and disease conditions. An imbalance can contribute to the decrease of the host's immune defenses and exacerbate the virulence of even opportunistic commensal bacteria, which in this case become pathogenic. In this context, polysaccharides of the bacteria cell surface play a critical role because they are one of the principal molecules which interact with the host immune system. Among these, the most important in Gram-positive bacteria are teichoic acids (TAs), capsular polysaccharides (CPSs) and exopolysaccharides (EPSs). For these reasons, the main effort of this Ph.D. thesis is to isolate polysaccharides produced by Gram-positive bacteria of various microbiota with the aim to structurally characterized them and to investigate their immunological properties. Specifically, the obtained glycans come from: Lactobacillus reuteri, Lactobacillus rhamnosus GG ATCC 53103, Lacticaseibacillus paracasei CBA L74, Bacillus subtilis 168, Ruminococcus gnavus ATCC 35913, and Enterococcus faecium U0317.
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