Quintavalle, Cristina (2010) Multifunctional roles of microRNAs in human glioblastoma. [Tesi di dottorato] (Unpublished)

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Item Type: Tesi di dottorato
Language: English
Title: Multifunctional roles of microRNAs in human glioblastoma
Creators:
CreatorsEmail
Quintavalle, Cristinacri_84@hotmail.it
Date: 29 November 2010
Number of Pages: 120
Institution: Università degli Studi di Napoli Federico II
Department: Biologia e patologia cellullare e molecolare "L. Califano"
Doctoral School: Medicina molecolare
PHD name: Patologia e fisiopatologia molecolare
PHD cycle: 23
PHD Coordinator:
nameemail
Avvedimento, Vittorio Enricoavvedim@unina.it
Tutor:
nameemail
Condorelli, Gerolamagecondor@unina.it
Date: 29 November 2010
Number of Pages: 120
Uncontrolled Keywords: microRNA , glioblastoma , motilità
MIUR S.S.D.: Area 06 - Scienze mediche > MED/04 - Patologia generale
Date Deposited: 10 Dec 2010 10:35
Last Modified: 17 Jun 2014 06:02
URI: http://www.fedoa.unina.it/id/eprint/8068

Abstract

Glioma are among the most deadly types of cancer. In spite of the enormous improvements made in neurosurgery, chemotherapy, and radiotherapy the prognosis of malignant glioma has remained poor over the last decade. Such bad efficacy in the management of glioma is largely attribuitable to resistance to therapeutic drugs and to the highly invasive nature of glioma cells capable of diffusely infiltrating and widely migrating in the surrounding brain tissue, leading to restricted and incomplete surgical resection and, thus, high recurrence rates. MicroRNAs (miRNA) represent a novel class of small RNAs that function as negative regulators of gene expression, deeply involved in the pathogenesis of several types of cancer. Different evidences indicate that miRNAs might play a fundamental role in tumorigenesis, cell proliferation, migration and apoptosis. The objective of this study is the identification and the functional characterization of microRNAs and their targets involved in resistance to therapeutics drugs (TRAIL, temozolomide) and in tumorigenesis of glioma cells.

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