Malara, Angela Eliana (2010) Effects of three different anti-ErbB2 antibodies on prostate tumors. [Tesi di dottorato] (Inedito)
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Effects of three different anti-ErbB2 antibodies on prostate tumors |
| Autori: | Autore Email Malara, Angela Eliana eliana.malara@unina.it |
| Data: | 29 Novembre 2010 |
| Numero di pagine: | 30 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Biologia strutturale e funzionale |
| Scuola di dottorato: | Scienze biologiche |
| Dottorato: | Biochimica e biologia cellulare e molecolare |
| Ciclo di dottorato: | 23 |
| Coordinatore del Corso di dottorato: | nome email Arcari, Paolo arcari@unina.it |
| Tutor: | nome email De Lorenzo, Claudia cladelo@unina.it |
| Data: | 29 Novembre 2010 |
| Numero di pagine: | 30 |
| Parole chiave: | ErbB2-Prostate cancer |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/10 - Biochimica |
| Depositato il: | 09 Dic 2010 16:49 |
| Ultima modifica: | 17 Giu 2014 06:02 |
| URI: | http://www.fedoa.unina.it/id/eprint/8140 |
Abstract
Prostate cancer is the most commonly diagnosed malignancy in men in developed countries. ErbB2 contributes to prostate cancer progression by activating the androgen receptor in a steroid poor environment, thus promoting androgen-independent cell growth and survival. The consequent development of hormone refractory tumors is a major obstacle in prostate cancer therapy. The inhibition of ErbB2 signal transduction pathways by the use of human antibodies has been considered as a valuable alternative strategy for cancer therapy. Herein we report a comparative analysis of the antitumor effects of three different antibodies targeting different epitopes of ErbB2: Herceptin (Trastuzumab), 2C4 (Pertuzumab), and Erb-hcAb, a novel fully human compact antibody produced in our laboratory. We demonstrate that the in vitro and in vivo growth of both androgen- dependent and –independent prostate cancer cells is efficiently inhibited by Erb-hcAb, which shows antitumor effects on some cell lines more potent than those observed for either Herceptin or 2C4
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