Della Vittoria Scarpati, Giuseppina (2010) New biomolecular prognostic and predictive factors of response to treatment in colo-rectal cancer. [Tesi di dottorato] (Inedito)
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | New biomolecular prognostic and predictive factors of response to treatment in colo-rectal cancer |
| Autori: | Autore Email Della Vittoria Scarpati, Giuseppina giuseppina.dellavittoria@alice.it |
| Data: | 29 Novembre 2010 |
| Numero di pagine: | 54 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Endocrinologia ed oncologia molecolare e clinica |
| Scuola di dottorato: | Medicina molecolare |
| Dottorato: | Oncologia ed endocrinologia molecolare |
| Ciclo di dottorato: | 23 |
| Coordinatore del Corso di dottorato: | nome email Santoro, Massimo [non definito] |
| Tutor: | nome email Pepe, Stefano stepepe@unina.it Cerrato, Aniello [non definito] |
| Data: | 29 Novembre 2010 |
| Numero di pagine: | 54 |
| Parole chiave: | colorectal cancer, prognostic and predictive factors, microRNA |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/06 - Oncologia medica |
| Depositato il: | 13 Dic 2010 14:38 |
| Ultima modifica: | 30 Apr 2014 19:44 |
| URI: | http://www.fedoa.unina.it/id/eprint/8143 |
| DOI: | 10.6092/UNINA/FEDOA/8143 |
Abstract
microRNAs are small single-stranded RNA molecules of approximately 22 nucleotides that function as post-transcriptional gene regulators. MiRNAs play important roles in the control of many biological processes, such as cellular development, differentiation, proliferation, apoptosis and metabolism. miRNA expression is aberrant in several human tumors. The biologic roles of miRNAs in cancer suggest a correlation with prognosis and therapeutic outcome. In our study, we examined by microarray the expression of 939 miRNArole in fresh biopsies of 39 patients affected by local advanced rectal cancer, treated with neoadjuvant chemoradiotherapy and surgery, with the aim to investigate the possible predictive and prognostic role. We have identified 14 miRNA which correlate significantly with Tumor Regression Grade 1. Our results suggest that miRNA expression profile could have relevance as prognostic and predictive factor of response to chemo-radiotherapy in colo-rectal cancer.
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