Wan Abdul Khodir, Wan Khartini (2011) NANOSTRUCTURED PLATFORMS WITH CONTROLLED DRUG DELIVERY FOR PERIODONTAL TISSUE REGENERATION. [Tesi di dottorato] (Inedito)

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: NANOSTRUCTURED PLATFORMS WITH CONTROLLED DRUG DELIVERY FOR PERIODONTAL TISSUE REGENERATION
Autori:
AutoreEmail
Wan Abdul Khodir, Wan Khartinitiniey_311@yahoo.com
Data: 30 Novembre 2011
Numero di pagine: 110
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Ingegneria dei materiali e della produzione
Scuola di dottorato: Ingegneria industriale
Dottorato: Ingegneria dei materiali e delle strutture
Ciclo di dottorato: 24
Coordinatore del Corso di dottorato:
nomeemail
Mensitieri, Giuseppemensitie@unina.it
Tutor:
nomeemail
Ambrosio, Luigiambrosio@unina.it
Guarino, Vincenzovguarino@unina.it
Data: 30 Novembre 2011
Numero di pagine: 110
Parole chiave: Electrospinning; electrospraying; drug delivery; periodontal surgery; tissue engineering
Settori scientifico-disciplinari del MIUR: Area 09 - Ingegneria industriale e dell'informazione > ING-IND/22 - Scienza e tecnologia dei materiali
Depositato il: 13 Dic 2011 11:55
Ultima modifica: 17 Giu 2014 06:03
URI: http://www.fedoa.unina.it/id/eprint/8899

Abstract

Electrospinning/electrospraying technique is currently represent a challenging route to produce polymer micro and nanoscaffolds with fibers and/or particles aspect. The design of integrated platforms based on the synergistic use of electrospinning and electrospraying technique offer the chance to design powerful scaffolds for tissue engineering and drug delivery applications. PCL and Chitosan are biocompatible materials to consider as ‘ideal’ candidates for cell material interation. In particular, PCL fibers may be electrospun to form submicrometric fibrous networks able to mimic the structural organization of the collagen fibres in the native ECM. Process parameters, i.e, voltage, flow rate, may be finely controlled optimize fiber size, distribution and beads occurrence. Meanwhile, chitosan particles processed by electrospraying can be successfully used as carrier of antibiotics, i.e, tetracycline for the use in periodontal surgery as confirmed by the fast release completed after 24 hours. Finally, the biological response of integrated systems was ultimately explored to validate the use of PCL/CHI scaffolds as periodontal patches.

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