Wan Abdul Khodir, Wan Khartini (2011) NANOSTRUCTURED PLATFORMS WITH CONTROLLED DRUG DELIVERY FOR PERIODONTAL TISSUE REGENERATION. [Tesi di dottorato] (Unpublished)

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Item Type:	Tesi di dottorato
Resource language:	English
Title:	NANOSTRUCTURED PLATFORMS WITH CONTROLLED DRUG DELIVERY FOR PERIODONTAL TISSUE REGENERATION
Creators:	Creators Email Wan Abdul Khodir, Wan Khartini tiniey_311@yahoo.com
Date:	30 November 2011
Number of Pages:	110
Institution:	Università degli Studi di Napoli Federico II
Department:	Ingegneria dei materiali e della produzione
Scuola di dottorato:	Ingegneria industriale
Dottorato:	Ingegneria dei materiali e delle strutture
Ciclo di dottorato:	24
Coordinatore del Corso di dottorato:	nome email Mensitieri, Giuseppe mensitie@unina.it
Tutor:	nome email Ambrosio, Luigi ambrosio@unina.it Guarino, Vincenzo vguarino@unina.it
Date:	30 November 2011
Number of Pages:	110
Keywords:	Electrospinning; electrospraying; drug delivery; periodontal surgery; tissue engineering
Settori scientifico-disciplinari del MIUR:	Area 09 - Ingegneria industriale e dell'informazione > ING-IND/22 - Scienza e tecnologia dei materiali
Date Deposited:	13 Dec 2011 11:55
Last Modified:	17 Jun 2014 06:03
URI:	http://www.fedoa.unina.it/id/eprint/8899

Collection description

Electrospinning/electrospraying technique is currently represent a challenging route to produce polymer micro and nanoscaffolds with fibers and/or particles aspect. The design of integrated platforms based on the synergistic use of electrospinning and electrospraying technique offer the chance to design powerful scaffolds for tissue engineering and drug delivery applications. PCL and Chitosan are biocompatible materials to consider as ‘ideal’ candidates for cell material interation. In particular, PCL fibers may be electrospun to form submicrometric fibrous networks able to mimic the structural organization of the collagen fibres in the native ECM. Process parameters, i.e, voltage, flow rate, may be finely controlled optimize fiber size, distribution and beads occurrence. Meanwhile, chitosan particles processed by electrospraying can be successfully used as carrier of antibiotics, i.e, tetracycline for the use in periodontal surgery as confirmed by the fast release completed after 24 hours. Finally, the biological response of integrated systems was ultimately explored to validate the use of PCL/CHI scaffolds as periodontal patches.

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