Medaglia, Chiara (2013) IN CATTLE HETEROZYGOSITY AT THE A625C POLYMORPHIC SITE OF THE MyD88 GENE IS ASSOCIATED WITH RESISTANCE TO Mycobacterium bovis. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: IN CATTLE HETEROZYGOSITY AT THE A625C POLYMORPHIC SITE OF THE MyD88 GENE IS ASSOCIATED WITH RESISTANCE TO Mycobacterium bovis
Creators:
CreatorsEmail
Medaglia, Chiarachiaramedaglia@libero.it
Date: 25 March 2013
Number of Pages: 44
Institution: Università degli Studi di Napoli Federico II
Department: Scienze del suolo, della pianta, dell'ambiente e delle produzioni animali
Scuola di dottorato: Scienze veterinarie per la produzione e la sanità
Dottorato: Produzione e sanità degli alimenti di origine animale
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Cortesi, Maria Luisamarialuisa.cortesi@unina.it
Tutor:
nomeemail
Ramunno, Luigiluigi.ramunno@unina.it
Date: 25 March 2013
Number of Pages: 44
Keywords: M. tuberculosis, MyD88, inflammation.
Settori scientifico-disciplinari del MIUR: Area 07 - Scienze agrarie e veterinarie > VET/04 - Ispezione degli alimenti di origine animale
Aree tematiche (7° programma Quadro): SALUTE e TUTELA DEL CONSUMATORE > Sicurezza alimentare, salute degli animali, benessere e salute degli animali e delle piante
Date Deposited: 11 Apr 2013 08:13
Last Modified: 31 Dec 2016 02:00
URI: http://www.fedoa.unina.it/id/eprint/9108

Collection description

The study demonstrates that in cattle the animals heterozygous at the MyD88 A625C polymorphic marker benefit of a five-fold reduced risk for active pulmonary tuberculosis (OR: 0.19; P: 6 x 10-12). The reduced risk however does not extend to the animals with latent pulmonary tuberculosis (OR: 0.83; P: 0.40). Heterozygosity at the A625C SNP is associated with intermediate levels of TNF- α,IFN-γ, and NO compared to the levels observed in the AA or CC homozygous genotypes. Deficiency as well as over-expression of pro-inflammatory cytokines favor tuberculosis. Thus, heterozygosity provides the animals with the optimal level of inflammation.

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