Spadaro, Olga (2013) Analysis of a novel thyroid-specific DNA binding activity in the Pax8 promoter. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Analysis of a novel thyroid-specific DNA binding activity in the Pax8 promoter
Creators:
CreatorsEmail
Spadaro, Olgaolga.spadaro@live.it
Date: 2 April 2013
Number of Pages: 50
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Veterinaria e Produzioni Animali
Scuola di dottorato: Scienze veterinarie per la produzione e la sanità
Dottorato: Organismi modello nella ricerca biomedica e veterinaria
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
De Girolamo, Paolodegirola@unina.it
Tutor:
nomeemail
Di Lauro, Robertordilauro@unina.it
Date: 2 April 2013
Number of Pages: 50
Uncontrolled Keywords: thyroid development - promoter - novel activity
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Aree tematiche (7° programma Quadro): BIOTECNOLOGIE, PRODOTTI ALIMENTARI E AGRICOLTURA > Scienze della vita, biotecnologia e biochimica per prodotti e processi non-alimentari sostenibili
Date Deposited: 05 Apr 2013 14:47
Last Modified: 09 May 2016 01:00
URI: http://www.fedoa.unina.it/id/eprint/9393

Abstract

Thyroid organogenesis requires the coexpression of the four transcription factors Pax8, Hhex, Foxe1 and Ttf-1 which mark a restricted number of cells in the ventral wall of the primitive pharynx as precursors of thyroid follicular cells. These factors act in a combinatorial way for which each controls the expression of the other but none of these alone induces the specification of thyroid precursors; to date there are no data available on the specification process. The study of cis-regulatory elements of thyroid specific selector genes would be the first step in the elucidation of the transactivating factors estabilishing the thyroid-specific molecular network. In particular we have been focused on the regulation of the pax8 gene that is the first of the four above mentioned selector genes to be expressed and we’ve found a novel thyroid-specific DNA binding activity on its promoter. The analysis of this DNA-activity could provide insights into the thyroid specification process.

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