Mastrovito, Paola (2014) LRRFIP1 negatively regulates IL-17 signalling by binding to CIKS. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: LRRFIP1 negatively regulates IL-17 signalling by binding to CIKS
Creators:
CreatorsEmail
Mastrovito, Paolapaola.mastrovito@gmail.com
Date: 31 March 2014
Number of Pages: 55
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Molecolare e Biotecnologie Mediche
Scuola di dottorato: Medicina molecolare
Dottorato: Patologia e fisiopatologia molecolare
Ciclo di dottorato: 26
Coordinatore del Corso di dottorato:
nomeemail
Avvedimento, Vittorio Enricovittorioenrico.avvedimento@unina.it
Tutor:
nomeemail
Leonardi, AntonioUNSPECIFIED
Date: 31 March 2014
Number of Pages: 55
Uncontrolled Keywords: LRRFIP1 isoform 3;IL-17;CIKS
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/04 - Patologia generale
Date Deposited: 10 Apr 2014 13:25
Last Modified: 15 Jul 2015 01:02
URI: http://www.fedoa.unina.it/id/eprint/9975

Abstract

Interleukin-17 (IL-17), the signature cytokine produced by T helper 17 (Th17) cells, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17 promotes the expression of cytokines and proteins involved in inflammatory responses, via the induction of gene transcription and post-transcription stabilization of mRNA. These functions are mediated by CIKS, an adaptor protein that is recruited to the receptor after IL-17 stimulation. We shows here that LRRFIP1 isoform 3 is a new CIKS interactor. Overexpression of LRRFIP1 isoform 3 blocks the IL-17 induced gene expression, via down-regulation of NF-κB and AP-1. Accordingly, down-regulation of LRRFIP1 enhanced the expression of cxcl1 and il-6 after IL-17 stimulation. LRRFIP 1 isoform 3 exerts this function by interfering with the recruitment of CIKS to the cytoplasmic domain of the IL-17 receptor. Collectively our finding defines a new mechanism regulating the inflammatory response.

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