Cioffi, Valentina (2025) Role of oxidative stress in SARS-CoV-2 induced diarrhea and comparative effects of postbiotic preparations obtained by strains recommended or not as treatment of acute gastroenteritis in human derived intestinal cells. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Role of oxidative stress in SARS-CoV-2 induced diarrhea and comparative effects of postbiotic preparations obtained by strains recommended or not as treatment of acute gastroenteritis in human derived intestinal cells |
| Autori: | Autore Email Cioffi, Valentina valentina.cioffi3@unina.it |
| Data: | 10 Dicembre 2025 |
| Numero di pagine: | 56 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Mediche Traslazionali |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 38 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco beguino@unina.it |
| Tutor: | nome email Guarino, Alfredo [non definito] |
| Data: | 10 Dicembre 2025 |
| Numero di pagine: | 56 |
| Parole chiave: | oxidative stress; SARS-CoV-2; Postbiotics |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica |
| Informazioni aggiuntive: | 38° |
| Depositato il: | 09 Gen 2026 10:11 |
| Ultima modifica: | 12 Ago 2026 05:37 |
| URI: | https://www.fedoa.unina.it/id/eprint/16040 |
Abstract
SARS-CoV-2 is now recognised as an enteric pathogen capable of inducing secretory diarrhea. Spike protein, which acts like an enterotoxin, triggers chloride secretion within the intestinal lumen and an increase in reactive oxygen species (ROS), similarly to the Rotavirus NSP4 protein. Previous in-vitro and in vivo studies have demonstrated the efficacy of strain-specific postbiotic preparations in reducing the intensity and duration of Rotavirus-related diarrhoea.This study aims to evaluate the efficacy of different postbiotic preparations derived from living microorganisms] in preventing Spike-induced chloride secretion and oxidative stress in human intestinal cells.
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