Braccia, Simone (2025) Design of smart peptide-based nanoplatforms for precision medicine. [Tesi di dottorato]

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• Sculture in marmo dalla Villa dei Papiri ad Ercolano. Contributo alla conoscenza delle botteghe di scultori di età romana in Campania. (deposited 18 Nov 2009 10:53)
  • Design of smart peptide-based nanoplatforms for precision medicine. (deposited 22 Dic 2025 10:19) [Attualmente visualizzato]

Abstract

The World Health Organization recognizes cancer as one of the leading causes of mortality worldwide. Conventional therapies, although characterized by high therapeutic efficacy, are often associated with severe side effects that significantly impair patients’ quality of life. Therefore, current research is increasingly focused on the development of precision medicine approaches based on targeted drug delivery systems, capable of improving selectivity and therapeutic outcomes while minimizing systemic toxicity. In this context, the present research focused on the design and optimization of innovative drug delivery systems aimed at overcoming the major limitations of conventional treatments. An anticancer delivery platform entirely composed of EPA, an omega-3 fatty acid, was developed and optimized to achieve controlled and site-specific drug release. This system was functionalized with peptide sequences designed to recognize overexpressed receptors on tumor cells and enable the selective release of Doxorubicin and Pemetrexed, in addition we added a cell penetrating peptide, namely gH625, to enhance intracellular uptake. In parallel, a cationic liposomal formulation was optimized for gene therapy applications, while a self-assembling amphiphilic peptide nanofiber nanosystem was engineered for the treatment of glioblastoma and for efficient gene delivery in TNBC treatment. The same nanofiber nanoplatform was further adapted for the treatment of fungal infections in the agri-food sector, with potential implications for preventing opportunistic infections in immuno-compromised patients. The integration of distinct components and functional peptide sequences enabled the development of smart, controlled-release nanoplatforms, representing a concrete step toward the realization of personalized precision medicine, tailored to the individual patient and guided by the synergy between multidisciplinary research and clinical needs.

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