Barrella, Valentina (2026) Diet-induced metabolic dysfunctions and probiotic-based preventive strategies. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Diet-induced metabolic dysfunctions and probiotic-based preventive strategies |
| Autori: | Autore Email Barrella, Valentina valentina.barrella@unina.it |
| Data: | 3 Marzo 2026 |
| Numero di pagine: | 73 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Biologia |
| Dottorato: | Biologia |
| Ciclo di dottorato: | 38 |
| Coordinatore del Corso di dottorato: | nome email Esposito, Sergio sergio.esposito@unina.it |
| Tutor: | nome email Iossa, Susanna [non definito] Baccigalupi, Loredana [non definito] |
| Data: | 3 Marzo 2026 |
| Numero di pagine: | 73 |
| Parole chiave: | Western diet, High-fructose diet, probiotics,gut microbiota, metabolic syndrome, inflammation, oxidative stress |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/09 - Fisiologia Area 05 - Scienze biologiche > BIO/19 - Microbiologia generale |
| Informazioni aggiuntive: | 38 ciclo PNRR |
| Depositato il: | 13 Mar 2026 09:54 |
| Ultima modifica: | 12 Ago 2026 05:37 |
| URI: | https://www.fedoa.unina.it/id/eprint/16152 |
Abstract
This PhD thesis investigates the effects of Western and high-fructose diets on gut and systemic metabolic homeostasis and evaluates probiotic-based preventive strategies in rat models. Diet-induced metabolic dysfunction was characterized by inflammation, oxidative stress, mitochondrial impairment, and insulin resistance affecting the gut–liver–muscle axis. Administration of Limosilactobacillus reuteri DSM 17938 and Shouchella clausii SF174 attenuated tissue-specific alterations, preserved intestinal barrier integrity, modulated gut microbiota composition, and improved mitochondrial function and insulin sensitivity. These findings support probiotics as promising nutritional strategies to counteract diet-induced metabolic disorders.
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