CASERTANO, MARIANNA (2026) EOSINOPHILIC ESOPHAGITIS IN THE PEDIATRIC AGE: PATHOPHYSIOLOGY, BIOMARKERS AND STRATEGIES FOR EARLY DIAGNOSIS. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | EOSINOPHILIC ESOPHAGITIS IN THE PEDIATRIC AGE: PATHOPHYSIOLOGY, BIOMARKERS AND STRATEGIES FOR EARLY DIAGNOSIS |
| Autori: | Autore Email CASERTANO, MARIANNA marianna.casertano@unina.it |
| Data: | 8 Giugno 2026 |
| Numero di pagine: | 63 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Mediche Traslazionali |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 38 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco beguino@unina.it |
| Tutor: | nome email Miele, Erasmo [non definito] |
| Data: | 8 Giugno 2026 |
| Numero di pagine: | 63 |
| Parole chiave: | eosinophilic esophagitis; pediatric; alarmins; microRNA; non-invasive biomarkers |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica |
| Informazioni aggiuntive: | Appartengo al ciclo 38 |
| Depositato il: | 12 Giu 2026 09:47 |
| Ultima modifica: | 12 Ago 2026 05:37 |
| URI: | https://www.fedoa.unina.it/id/eprint/16280 |
Abstract
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease of the esophagus with an incompletely understood pathogenesis and a nonspecific clinical presentation that often delays diagnosis. As diagnosis and follow-up still depend on invasive endoscopy with biopsy, reliable non-invasive biomarkers are needed. This thesis combines three studies in pediatric EoE: a molecular analysis of mucosal alarmins (TSLP isoforms, IL-33, IL-25, TL1A) and their receptors, revealing differential pathway regulation; the evaluation of plasma miR-21-5p and miR-223-3p, which mirror tissue expression and track histological response to therapy; and a clinical study in which symptom-based screening with the PEESS questionnaire allowed early identification of EoE in children with type 1 diabetes, showing an increased prevalence and a milder phenotype. Taken together, these results identify promising molecular and clinical tools to improve the early recognition and follow-up of pediatric EoE.
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