Costanzo, Mattia CANNABINOID SYSTEM SUSTAINS AN INFLAMMATION RESOLUTION RESPONSE THROUGH WHICH EXPANDS ITS ANTI-TUMOR EFFECTS IN GASTROINTESTINAL CANCER. [Tesi di dottorato]
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Documento PDF
TesiDottoratoMattiaCostanzo.pdf Visibile a [TBR] Amministratori dell'archivio Download (2MB) | Richiedi una copia |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | CANNABINOID SYSTEM SUSTAINS AN INFLAMMATION RESOLUTION RESPONSE THROUGH WHICH EXPANDS ITS ANTI-TUMOR EFFECTS IN GASTROINTESTINAL CANCER |
| Autori: | Autore Email Costanzo, Mattia mattcostanzo1595@gmail.com |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Mediche Traslazionali |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 37 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco [non definito] |
| Tutor: | nome email Prevete, Nella [non definito] |
| Parole chiave: | Cannabinoid system, Specialized pro-resolving mediators (SPMs), Gastrointestinal cancer |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/05 - Patologia clinica |
| Informazioni aggiuntive: | APPARTENGO AL 37 CICLO, che secondo avviso per problema tecnico del sito non è possibile selezionare. |
| Depositato il: | 17 Ott 2025 14:42 |
| Ultima modifica: | 09 Ago 2026 05:57 |
| URI: | https://www.fedoa.unina.it/id/eprint/16366 |
Abstract
Gastrointestinal (GI) cancers are linked to chronic low-grade inflammation. ‘Bioactive lipids’ are key players in regulating inflammatory response. The main classes of bioactive lipids are: eicosanoids, specialized pro-resolving mediators (SPMs), lysoglycerophospholipids-sphingolipids and endocannabinoids (eCBs). Dysregulation of these lipids has been linked to several diseases with an inflammatory pathogenesis including cancer. We described a novel function of SPMs demonstrating that two SPMs (i.e. RvD1 and LXB4) suppress angiogenesis, thus inhibiting GI tumor growth. In the GI context, CBs induce apoptosis and necrosis of cancer cells. To date, several reports suggest a link between SPM and eCB pathways, highlighting common precursors, metabolic enzymes, and the possibility that one class of lipid could exert its functions by sustaining the production of the other one. We aimed at evaluating a plausible cross-talk between functional activity of eCBs and SPMs in GI cancers.
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