Nasir, Saad (2025) Evaluation of the effects of oil-derived Nacylethanolamides mixture (Olaliamid) on cardiovascular parameters, metabolic, inflammatory, and oxidative status, in naturally obese dogs: a double-blind, randomized, placebo controlled study. [Tesi di dottorato]
![[thumbnail of PHDTHESISCICLO37SAADNASIRFEBRUARY2025.pdf]](https://www.fedoa.unina.it/style/images/fileicons/other.png "PHDTHESISCICLO37SAADNASIRFEBRUARY2025.pdf") |
Documento PDF
PHDTHESISCICLO37SAADNASIRFEBRUARY2025.pdf Visibile a [TBR] Utenti registrati Download (1MB) | Richiedi una copia |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Evaluation of the effects of oil-derived Nacylethanolamides mixture (Olaliamid) on cardiovascular parameters, metabolic, inflammatory, and oxidative status, in naturally obese dogs: a double-blind, randomized, placebo controlled study |
| Autori: | Autore Email Nasir, Saad saad.nasir@unina.it |
| Data: | 10 Febbraio 2025 |
| Numero di pagine: | 109 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Veterinaria e Produzioni Animali |
| Dottorato: | Scienze veterinarie |
| Ciclo di dottorato: | 37 |
| Coordinatore del Corso di dottorato: | nome email De Girolamo, Paolo paolo.degirolamo@unina.it |
| Tutor: | nome email Cortese, Laura [non definito] |
| Data: | 10 Febbraio 2025 |
| Numero di pagine: | 109 |
| Parole chiave: | Olaliamid, Obesity, Dog, Oxidative Stress, Metabolic Status |
| Settori scientifico-disciplinari del MIUR: | Area 07 - Scienze agrarie e veterinarie > VET/08 - Clinica medica veterinaria |
| Informazioni aggiuntive: | Appartenente al 37mo ciclo |
| Depositato il: | 17 Feb 2025 09:54 |
| Ultima modifica: | 09 Ago 2026 06:05 |
| URI: | https://www.fedoa.unina.it/id/eprint/16702 |
Abstract
Canine obesity is a common disorder accompanied by low-grade chronic inflammation and a risk factor for liver and heart disorders. The present study aimed to investigate whether an olive oil derivative enriched in N-acyl-ethanolamines (Olaliamid®, OLA) may protect dogs against obesity-induced comorbidities. Twenty seven dogs of any breed and size with body condition score ≥7/9 were included, provided they were otherwise healthy. Dogs were fed a commercial maintenance diet for two weeks before enrolment, and randomized in two groups of treatment, i.e., OLA(n=14) and placebo (OLA vehicle; n=13). Both treatments were administered orally in a liquid form at 0.7 ml/5kg body weight, once a day for 3 months. At baseline and 3 months later dogs underwent physical examination, blood draw, and echocardiography (Mindray DC-90, Cina). At the same timepoints, owners were given a questionnaire about their dog’s general condition. OLA prevented the increase in leptin observed in the placebo group (P = 0.011), decreased IL-6 (P = 0.042) and derivatives-reactive oxygen metabolites (d-ROMs, P = 0.008), and increased biological antioxidant potential (BAP) compared to the placebo group (P = 0.032). Moreover, OLA protected the liver, with ALT levels being decreased in the OLA compared to the placebo group (P=0.005) and bilirubin levels being decreased in the OLA (P = 0.030) but not in the placebo group. OLA showed a cardioprotective effect, with a significant decrease of IVSdN (P=0.028), LVPWdN (P=0.047), IVSd/LVIDd (P=0.015) and LVPWd/LVIDd (P=0.034) compared to the placebo group. According to dog owners, difficulty rising from lying down significantly increased in the placebo (P=0.035) but not in the OLA group. Overall, OLA was effective against markers of obesity-induced meta inflammation and oxidative status and helped to improve liver and heart health as well.
Downloads
Downloads per month over past year
Actions (login required)
 |
Modifica documento |
