Pisani, Francesco (2025) Gold Nanoparticles-Decorated Ti₃C₂Tₓ 2D Nanomaterials for Innovative Technologies in Biosensing. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Gold Nanoparticles-Decorated Ti₃C₂Tₓ 2D Nanomaterials for Innovative Technologies in Biosensing |
| Autori: | Autore Email Pisani, Francesco francesco.pisani@unina.it |
| Data: | 10 Giugno 2025 |
| Numero di pagine: | 144 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Fisica |
| Dottorato: | Fisica |
| Ciclo di dottorato: | 37 |
| Coordinatore del Corso di dottorato: | nome email Canale, Vincenzo vincenzo.canale@unina.it |
| Tutor: | nome email Iannotti, VIncenzo [non definito] Velotta, Raffaele [non definito] Granata, Carmine [non definito] Tessicini, Fabrizio [non definito] |
| Data: | 10 Giugno 2025 |
| Numero di pagine: | 144 |
| Parole chiave: | 2D Nanomaterials, MXene, Gold Nanoparticles, Biosensing |
| Settori scientifico-disciplinari del MIUR: | Area 02 - Scienze fisiche > FIS/03 - Fisica della materia Area 02 - Scienze fisiche > FIS/07 - Fisica applicata (a beni culturali, ambientali, biologia e medicina) |
| Informazioni aggiuntive: | Il mio è il ciclo 37 |
| Depositato il: | 18 Ott 2025 15:41 |
| Ultima modifica: | 12 Ago 2026 05:38 |
| URI: | https://www.fedoa.unina.it/id/eprint/16785 |
Abstract
This thesis explores novel applications and properties of nanomaterials for the development of biosensors aimed at detecting biological targets relevant to diagnostics, environmental monitoring, and food safety. Specifically, it focuses on a class of two-dimensional (2D) materials known as MXenes—layered structures composed of transition metal carbides with surface terminations such as oxygen, fluorine, and hydroxyl groups. In particular, we investigate coating techniques using gold nanoparticles to transform this 2D nanomaterial into potential markers for biological target recognition. The resulting nanocomposite, referred to as AuNPs@Ti₃C₂Tₓ or AuNPs@MXene, consists of gold nanoparticles (AuNPs) anchored onto the MXene surface (Ti₃C₂Tₓ), where Tₓ denotes surface functional groups. For biosensing purposes, the AuNPs@Ti₃C₂Tₓ were functionalized with antibodies using a photoimmobilization technique, thereby enhancing their potential as biosensing markers. The thesis presents characterizations of the synthesized material to assess its physical and chemical properties, which were subsequently utilized in biosensing experiments. These experiments involved the detection of IgG antigens and demonstrated concentration-dependent agglomeration of the nanocomposite flakes, leading to larger and flatter structures, as confirmed by multiple nanomaterial sizing techniques.
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