Elia, Valerio Cosimo (2025) Mitigation of radiation-induced damage to healthy tissues: an in-vitro and ex-vivo characterization of novel nutraceutical compounds for possible use in radiotherapy. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Mitigation of radiation-induced damage to healthy tissues: an in-vitro and ex-vivo characterization of novel nutraceutical compounds for possible use in radiotherapy |
| Autori: | Autore Email Elia, Valerio Cosimo valeriocosimo.elia@unina.it |
| Data: | 26 Agosto 2025 |
| Numero di pagine: | 102 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Fisica |
| Dottorato: | Fisica |
| Ciclo di dottorato: | 37 |
| Coordinatore del Corso di dottorato: | nome email Canale, Vincenzo vincenzo.canale@unina.it |
| Tutor: | nome email Manti, Lorenzo [non definito] |
| Data: | 26 Agosto 2025 |
| Numero di pagine: | 102 |
| Parole chiave: | Ionizing radiation, Radiotherapy, DNA damage, Nutraceuticals, Radioprotection |
| Settori scientifico-disciplinari del MIUR: | Area 02 - Scienze fisiche > FIS/07 - Fisica applicata (a beni culturali, ambientali, biologia e medicina) |
| Informazioni aggiuntive: | Appartengo al 37° ciclo PON |
| Depositato il: | 18 Ott 2025 15:41 |
| Ultima modifica: | 12 Ago 2026 05:38 |
| URI: | https://www.fedoa.unina.it/id/eprint/16801 |
Abstract
Ionizing radiation (IR) is widely employed in medicine, yet its biological impact, particularly during radiotherapy (RT), poses significant risks to healthy tissues, including DNA damage, chronic inflammation, and secondary malignancies. Understanding the mechanisms underlying IR-induced effects is therefore crucial for the development of effective radioprotective strategies. In this context, growing attention has been directed toward nutraceuticals, food-derived compounds with antioxidant and anti-inflammatory properties that may mitigate oxidative stress and modulate cellular responses. This thesis investigates the potential of nutraceuticals as radioprotective agents through in vitro and ex vivo studies, evaluating their ability to reduce IR-induced damage, promote DNA repair, and enhance tissue tolerance to treatment. The findings provide new insights into the integration of nutraceutical approaches in clinical practice, aiming to optimize RT efficacy while minimizing long-term side effects.
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