Bardi, Luca (2025) Effects of intracoronary nitrate administration on invasive assessment of coronary microcirculation: insights from the INOCA Na registry. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Effects of intracoronary nitrate administration on invasive assessment of coronary microcirculation: insights from the INOCA Na registry |
| Autori: | Autore Email Bardi, Luca luca.bardi@unina.it |
| Data: | 5 Dicembre 2025 |
| Numero di pagine: | 37 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dottorato: | Cardiovascular Pathophysiology and Therapeutics |
| Ciclo di dottorato: | 38 |
| Coordinatore del Corso di dottorato: | nome email Esposito, Giovanni esposito.giovanni@unina.it |
| Tutor: | nome email Esposito, Giovanni [non definito] |
| Data: | 5 Dicembre 2025 |
| Numero di pagine: | 37 |
| Parole chiave: | INOCA |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare |
| Informazioni aggiuntive: | CICLO DI EFFETTIVA APPARTENENZA 38. |
| Depositato il: | 19 Dic 2025 15:17 |
| Ultima modifica: | 12 Ago 2026 05:38 |
| URI: | https://www.fedoa.unina.it/id/eprint/17024 |
Abstract
Ischemia with non-obstructive coronary artery disease (INOCA) represents a heterogeneous clinical entity characterized by angina and objective evidence of myocardial ischemia despite the absence of obstructive epicardial coronary disease. INOCA encompasses both microvascular dysfunction (CMD) and coronary spasm leading to vasospastic angina (VSA), conditions associated with increased morbidity, mortality, and poor quality of life. Although invasive full physiology coronary angiography (FCA) has emerged as the gold standard for endotype classification, the influence of intracoronary nitrate administration on the measurement of invasive functional indices remains underexplored and there are concerns about the timing for its administration. This study aimed to evaluate whether preventive intracoronary administration of NTG significantly affects hemodynamic parameters and the diagnostic accuracy of functional coronary angiography.
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