De Lella, Sabrina (2025) Characterization of RNA-binding proteins in ovarian cancer progression and platinum resistance. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Characterization of RNA-binding proteins in ovarian cancer progression and platinum resistance |
| Autori: | Autore Email De Lella, Sabrina sabrina.delella@unina.it |
| Data: | 7 Dicembre 2025 |
| Numero di pagine: | 86 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dottorato: | Medicina molecolare e biotecnologie mediche |
| Ciclo di dottorato: | 38 |
| Coordinatore del Corso di dottorato: | nome email Santoro, Massimo massimo.santoro@unina.it |
| Tutor: | nome email Esposito, Franca [non definito] |
| Data: | 7 Dicembre 2025 |
| Numero di pagine: | 86 |
| Parole chiave: | Ovarian cancer, RNA-binding proteins, Cisplatin resistance |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/10 - Biochimica Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare |
| Informazioni aggiuntive: | Ciclo di Dottorato 38 |
| Depositato il: | 22 Dic 2025 10:02 |
| Ultima modifica: | 12 Ago 2026 05:39 |
| URI: | https://www.fedoa.unina.it/id/eprint/17056 |
Abstract
RNA-binding proteins (RBPs) are emerging as crucial modulators of post-transcriptional regulation in cancer biology. In this thesis, it has been investigated the role of two RBPs, TRAP1 and ANXA11, in the context of high-grade serous ovarian cancer (HGSOC) and cisplatin resistance, by integrating bioinformatic analyses with experimental approaches. TRAP1, previously described only as a molecular chaperone, was identified in several RBPomes and characterized here as a novel non canonical RBP. Findings obtained demonstrate that TRAP1 promotes tumorigenesis through its RNA-binding activity, favoring the translation of the splicing factor LUC7L3 and thereby unraveling a new layer of its oncogenic potential. In parallel, ANXA11, traditionally linked to neurodegenerative disorders, emerged as an RBP whose expression is enriched in cisplatin-resistant HGSOC cells. Functional analyses revealed that ANXA11 contributes to both drug resistance and enhanced aggressiveness, highlighting its role as a determinant of the chemoresistant phenotype. Together, these results expand our knowledge regarding TRAP1 and ANXA11, shedding light on their contribution in ovarian cancer progression and their potential as novel therapeutic targets.
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