Coda, Marco (2015) Experimental study on bioactive molecules in contrasting dental diseases: microbiological assay, oral delivering and enamel remineralization. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Experimental study on bioactive molecules in contrasting dental diseases: microbiological assay, oral delivering and enamel remineralization |
| Creators: | Creators Email Coda, Marco marcocoda@fastwebnet.it |
| Date: | 30 March 2015 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Neuroscienze e Scienze Riproduttive ed Odontostomatologiche |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Scienze odontostomatologiche |
| Ciclo di dottorato: | 27 |
| Coordinatore del Corso di dottorato: | nome email Rengo, Sandro sandro.rengo@unina.it |
| Tutor: | nome email Ingenito, Aniello UNSPECIFIED |
| Date: | 30 March 2015 |
| Keywords: | caries erosion prevention CPP polyphenols |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/28 - Malattie odontostomatologiche |
| Date Deposited: | 13 Apr 2015 20:28 |
| Last Modified: | 25 Sep 2015 09:38 |
| URI: | http://www.fedoa.unina.it/id/eprint/10300 |
| DOI: | 10.6092/UNINA/FEDOA/10300 |
Collection description
The objective of this research program was to determine a new way in caries and erosion prevention. To achieve this target was analyzed the more effective anti-caries and anti-erosive bio-active molecules of natural origin, in order to elaborate a new novel chewing gum device. The under discussion molecules were plant polyphenols and casein-phosphopeptides. The research project has been divided in three parts: initially, was analyzed in vitro, through SEM inspection and pH analysis, the remineralizing effect of casein-phosphopeptides against cola drink dental erosion. In the second part, a microbiological assay of effects of Plantago lanceolata tea on oral bacteria was assessed: initially, the P. lanceolata tea was chemical analyzed for its polyphenolic content; then, the MIC and MBC were determined for P. lanceolata extracts against cariogenic bacteria; subsequently, a controlled random clinical study was conducted on 44 volunteers to evaluate a P. lanceolata-based mouth rinse on cariogenic bacteria content in saliva. In the third part, in vitro experiments were performed using a specifically designed chewing apparatus to test the release in artificial saliva of Calcium (derived from CPP) and Quercetin included in gums, during the chewing time; while the in vivo experiments required a two sessions clinical trial, performed by 10 volunteers, in order to analyze the in vivo performance of the experimental chewing-gums.
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