Coda, Marco
(2015)
Experimental study on bioactive molecules in contrasting dental diseases: microbiological assay, oral delivering and enamel remineralization.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Experimental study on bioactive molecules in contrasting dental diseases: microbiological assay, oral delivering and enamel remineralization |
| Autori: |
| Autore | Email |
|---|
| Coda, Marco | marcocoda@fastwebnet.it |
|
| Data: |
30 Marzo 2015 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Neuroscienze e Scienze Riproduttive ed Odontostomatologiche |
| Scuola di dottorato: |
Medicina clinica e sperimentale |
| Dottorato: |
Scienze odontostomatologiche |
| Ciclo di dottorato: |
27 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Rengo, Sandro | sandro.rengo@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Ingenito, Aniello | [non definito] |
|
| Data: |
30 Marzo 2015 |
| Parole chiave: |
caries erosion prevention CPP polyphenols |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/28 - Malattie odontostomatologiche |
[error in script]
[error in script]
| Depositato il: |
13 Apr 2015 20:28 |
| Ultima modifica: |
25 Set 2015 09:38 |
| URI: |
http://www.fedoa.unina.it/id/eprint/10300 |
| DOI: |
10.6092/UNINA/FEDOA/10300 |
Abstract
The objective of this research program was to determine a new way in caries and erosion prevention. To achieve this target was analyzed the more effective anti-caries and anti-erosive bio-active molecules of natural origin, in order to elaborate a new novel chewing gum device. The under discussion molecules were plant polyphenols and casein-phosphopeptides.
The research project has been divided in three parts: initially, was analyzed in vitro, through SEM inspection and pH analysis, the remineralizing effect of casein-phosphopeptides against cola drink dental erosion. In the second part, a microbiological assay of effects of Plantago lanceolata tea on oral bacteria was assessed: initially, the P. lanceolata tea was chemical analyzed for its polyphenolic content; then, the MIC and MBC were determined for P. lanceolata extracts against cariogenic bacteria; subsequently, a controlled random clinical study was conducted on 44 volunteers to evaluate a P. lanceolata-based mouth rinse on cariogenic bacteria content in saliva. In the third part, in vitro experiments were performed using a specifically designed chewing apparatus to test the release in artificial saliva of Calcium (derived from CPP) and Quercetin included in gums, during the chewing time; while the in vivo experiments required a two sessions clinical trial, performed by 10 volunteers, in order to analyze the in vivo performance of the experimental chewing-gums.
Downloads per month over past year
Actions (login required)
 |
Modifica documento |
