Vilardi, Emanuela
(2015)
Tissue-engineered matrix as functional delivery system: Controlled release of bioactive pro-angiogenic peptide from degradable PCL scaffold.
[Tesi di dottorato]
| Item Type: |
Tesi di dottorato
|
| Resource language: |
English |
| Title: |
Tissue-engineered matrix as functional delivery system: Controlled release of bioactive pro-angiogenic peptide from degradable PCL scaffold. |
| Creators: |
| Creators | Email |
|---|
| Vilardi, Emanuela | Emanuela.vilardi@unina.it |
|
| Date: |
31 March 2015 |
| Number of Pages: |
102 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Ingegneria Chimica, dei Materiali e della Produzione Industriale |
| Scuola di dottorato: |
Ingegneria industriale |
| Dottorato: |
Ingegneria dei materiali e delle strutture |
| Ciclo di dottorato: |
27 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Mensitieri, Giuseppe | giuseppe.mensitieri@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Netti, Paolo Antonio | UNSPECIFIED |
|
| Date: |
31 March 2015 |
| Number of Pages: |
102 |
| Keywords: |
bioactive scaffold, proangiogenic factor |
| Settori scientifico-disciplinari del MIUR: |
Area 09 - Ingegneria industriale e dell'informazione > ING-IND/22 - Scienza e tecnologia dei materiali |
| Aree tematiche (7° programma Quadro): |
NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Nanoscienze e Nanotecnologie
NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Materiali |
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| Date Deposited: |
12 Apr 2015 01:58 |
| Last Modified: |
30 Apr 2016 01:00 |
| URI: |
http://www.fedoa.unina.it/id/eprint/10482 |
| DOI: |
10.6092/UNINA/FEDOA/10482 |
Collection description
In tissue engineering in fact, angiogenesis is a process of fundamental importance in many physiological processes such as normal tissue growth, being responsible of creating a vascular network capable of providing oxygen and nutrients to the neo-formed tissue.
Vessel formation is mediated by specific soluble growth factors, such as Vascular-Endothelial Growth Factor.
Biocompatible scaffolds represent a valuable structural support, but also as a potential guide for regenerative processes. They must satisfy specific physical and mechanical properties, such as a high, interconnected porosity, mechanical strength and in addition to satisfying the obvious requests of biocompatibility. This work aims to analyze the bioactive potential of a scaffold designed with a "bottom up" technique in which the construct is seen as the assembly of single units (building blocks) each with its on specific, pre-designed, function.we developed an assembly procedure based on solvent sinterization of microspherical building blocks. These constructs were loaded with interspersing PLGA drug delivery systems (DDSs) for the release of angiogenic factors or similar molecules.Specifically, QK, the "engineered VEGF mimicking peptide" was loaded onto these DDS.
We wanted to demonstrate that QK maintains its pro-angiogenic activity in the context of an application in which PCL scaffolds, made following a bottom up approach, are loaded with DDS controlled release.
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