Mastantuono, Teresa (2015) Oscillazioni del flusso microvascolare in pazienti obesi iperglicemici. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | Italiano |
| Title: | Oscillazioni del flusso microvascolare in pazienti obesi iperglicemici |
| Creators: | Creators Email Mastantuono, Teresa teresa.mastantuono@libero.it |
| Date: | 31 March 2015 |
| Number of Pages: | 129 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Medicina Clinica e Chirurgia |
| Scuola di dottorato: | Medicina preventiva, pubblica e sociale |
| Dottorato: | Scienze dell'alimentazione e della nutrizione |
| Ciclo di dottorato: | 27 |
| Coordinatore del Corso di dottorato: | nome email Contaldo, Franco UNSPECIFIED |
| Tutor: | nome email Colantuoni, Antonio UNSPECIFIED |
| Date: | 31 March 2015 |
| Number of Pages: | 129 |
| Keywords: | Flusso microvascolare, laser Doppler, iperglicemia |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/09 - Fisiologia |
| Aree tematiche (7° programma Quadro): | SALUTE e TUTELA DEL CONSUMATORE > Biotecnologie, strumenti e tecnologie generiche per la salute umana |
| Date Deposited: | 08 Apr 2015 09:51 |
| Last Modified: | 13 Apr 2016 01:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/10489 |
| DOI: | 10.6092/UNINA/FEDOA/10489 |
Collection description
Aim: The present study was aimed to investigate skin microvascular blood flow oscillations by noninvasively LDPM and to evaluate the effects of insulin resistance and hyperglycemia on skin perfusion in obese subjects. Furthermore, we assessed the effects of hypocaloric diet on skin microvascular blood flow in newly diagnosed hyperglicemic obese patients. Methods: Fifty-four normoglycemic (27 females) and fifty-four hyperglycemic (27 females) obese adults were recruited from our Outpatient Clinic and treated with hypocaloric diet for 6 months. Skin microvascular blood flow was recorded by laser Doppler flowmeter and blood flow oscillations were analyzed by wavelet transform. Moreover, reactive hyperemia, due to 2 min brachial artery occlusion, was investigated in fourteen normoglycemic (7 females) and sixteen hyperglycemic (8 females) obese adults. Results: Skin microvascular blood flow (9.4 ± 0.3 vs 11.8 ± 0.4 PU, p<0.01) and total power spectral density (PSD: 113.2 ± 10.1 vs 176.5 ± 11.4 PU2/Hz, p<0.01) were lower in the hyperglycemic than normoglycemic people. Among the frequency components of blood flow oscillations, myogenic activity spectral density was lower in hyperglycemic than normoglycemic patients (31.0 ± 0.7 vs 34.9 ± 0.7 %, p<0.01). Moreover, hyperglycemic subjects showed lower hyperemic response to artery occlusion compared to the corresponding one observed in normoglycemic patients. After 6 month hypocaloric diet, blood flow and spectral denisty significantly increased in hyperglycemic subjects. Myogenic activity-related oscillatory component spectral density was enhanced, while post-occlusive reactive hyperemia significantly improved. Conclusions: In conclusion, insulin resistance- and hyperglycemia-associated microvascular alterations severely affect peripheral resistance and tissue perfusion. Hypocaloric diet appeared to ameliorate arteriolar dilation and blood flow redistribution to tissue.
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