Squillace, Marta (2016) Biological function of D-aspartate in the mammalian brain. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Biological function of D-aspartate in the mammalian brain |
| Creators: | Creators Email Squillace, Marta squillace2003@libero.it |
| Date: | 29 March 2016 |
| Number of Pages: | 75 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Scienze Chimiche |
| Scuola di dottorato: | Scienze chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 28 |
| Coordinatore del Corso di dottorato: | nome email Paduano, Luigi lpaduano@unina.it |
| Tutor: | nome email Pucci, Piero UNSPECIFIED |
| Date: | 29 March 2016 |
| Number of Pages: | 75 |
| Keywords: | D-Aspartate; NMDAR; Schizophrenia; |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/10 - Biochimica Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 05 - Scienze biologiche > BIO/12 - Biochimica clinica e biologia molecolare clinica Area 03 - Scienze chimiche > CHIM/01 - Chimica analitica |
| Date Deposited: | 11 Apr 2016 16:56 |
| Last Modified: | 30 May 2017 01:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/10779 |
Collection description
D-Asp is highly concentrated in the prenatal brain; after birth, its levels sharply decrease due to the catabolising activity of the enzyme D-aspartate oxidase. D-Asp is able to stimulate NMDAR-dependent neurotransmission through direct action at the glutamate-binding site of NMDARs, thus functioning as an endogenous agonist for this subclass of glutamate receptors. The agonistic activity exerted by D-Asp on NMDARs and its neurodevelopmental occurrence make this D-amino acid a potential mediator for some of the NMDAR-related alterations observed in schizophrenia. Therefore, aim of the research is to investigate about the potential role of D-Asp in schizophrenia-relevant circuits and behaviors.
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