Squillace, Marta (2016) Biological function of D-aspartate in the mammalian brain. [Tesi di dottorato]

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Item Type:	Tesi di dottorato
Lingua:	English
Title:	Biological function of D-aspartate in the mammalian brain
Creators:	Creators Email Squillace, Marta squillace2003@libero.it
Date:	29 March 2016
Number of Pages:	75
Institution:	Università degli Studi di Napoli Federico II
Department:	Scienze Chimiche
Scuola di dottorato:	Scienze chimiche
Dottorato:	Scienze chimiche
Ciclo di dottorato:	28
Coordinatore del Corso di dottorato:	nome email Paduano, Luigi lpaduano@unina.it
Tutor:	nome email Pucci, Piero UNSPECIFIED
Date:	29 March 2016
Number of Pages:	75
Uncontrolled Keywords:	D-Aspartate; NMDAR; Schizophrenia;
Settori scientifico-disciplinari del MIUR:	Area 05 - Scienze biologiche > BIO/10 - Biochimica Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 05 - Scienze biologiche > BIO/12 - Biochimica clinica e biologia molecolare clinica Area 03 - Scienze chimiche > CHIM/01 - Chimica analitica
Date Deposited:	11 Apr 2016 16:56
Last Modified:	30 May 2017 01:00
URI:	http://www.fedoa.unina.it/id/eprint/10779

Abstract

D-Asp is highly concentrated in the prenatal brain; after birth, its levels sharply decrease due to the catabolising activity of the enzyme D-aspartate oxidase. D-Asp is able to stimulate NMDAR-dependent neurotransmission through direct action at the glutamate-binding site of NMDARs, thus functioning as an endogenous agonist for this subclass of glutamate receptors. The agonistic activity exerted by D-Asp on NMDARs and its neurodevelopmental occurrence make this D-amino acid a potential mediator for some of the NMDAR-related alterations observed in schizophrenia. Therefore, aim of the research is to investigate about the potential role of D-Asp in schizophrenia-relevant circuits and behaviors.

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