Squillace, Marta (2016) Biological function of D-aspartate in the mammalian brain. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Biological function of D-aspartate in the mammalian brain
Creators:
CreatorsEmail
Squillace, Martasquillace2003@libero.it
Date: 29 March 2016
Number of Pages: 75
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Chimiche
Scuola di dottorato: Scienze chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 28
Coordinatore del Corso di dottorato:
nomeemail
Paduano, Luigilpaduano@unina.it
Tutor:
nomeemail
Pucci, PieroUNSPECIFIED
Date: 29 March 2016
Number of Pages: 75
Uncontrolled Keywords: D-Aspartate; NMDAR; Schizophrenia;
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/10 - Biochimica
Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 05 - Scienze biologiche > BIO/12 - Biochimica clinica e biologia molecolare clinica
Area 03 - Scienze chimiche > CHIM/01 - Chimica analitica
Date Deposited: 11 Apr 2016 16:56
Last Modified: 30 May 2017 01:00
URI: http://www.fedoa.unina.it/id/eprint/10779

Abstract

D-Asp is highly concentrated in the prenatal brain; after birth, its levels sharply decrease due to the catabolising activity of the enzyme D-aspartate oxidase. D-Asp is able to stimulate NMDAR-dependent neurotransmission through direct action at the glutamate-binding site of NMDARs, thus functioning as an endogenous agonist for this subclass of glutamate receptors. The agonistic activity exerted by D-Asp on NMDARs and its neurodevelopmental occurrence make this D-amino acid a potential mediator for some of the NMDAR-related alterations observed in schizophrenia. Therefore, aim of the research is to investigate about the potential role of D-Asp in schizophrenia-relevant circuits and behaviors.

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