Di Palo, Giacomo (2016) The Intertwined Roles of DNA Damage and Transcription. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: The Intertwined Roles of DNA Damage and Transcription
Creators:
CreatorsEmail
Di Palo, Giacomogiacomo.dipalo@unina.it
Date: 30 March 2016
Number of Pages: 69
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Molecolare e Biotecnologie Mediche
Scuola di dottorato: Medicina molecolare
Dottorato: Genetica e medicina molecolare
Ciclo di dottorato: 28
Coordinatore del Corso di dottorato:
nomeemail
Nitsch, Luciolucio.nitsch@unina.it
Tutor:
nomeemail
Lania, LuigiUNSPECIFIED
Date: 30 March 2016
Number of Pages: 69
Uncontrolled Keywords: DNA damage, transcription, OxiDIP-Seq, 8oxodG, double-strand brea
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 05 - Scienze biologiche > BIO/18 - Genetica
Area 01 - Scienze matematiche e informatiche > INF/01 - Informatica
Date Deposited: 13 Apr 2016 11:59
Last Modified: 31 Oct 2016 09:53
URI: http://www.fedoa.unina.it/id/eprint/10833

Abstract

DNA damage and transcription are two interconnected events. Transcription can induce damage and scheduled DNA damage can be required for transcription. Here, we analyzed genome-wide distribution of 8oxodG-marked oxidative DNA damage obtained by OxiDIP-Seq, and we found a correlation with transcription of protein coding genes.

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