Caso, Maria Federica (2016) New synthetic routes to the stereoselective assembly and the elaboration of bioactive compounds. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | New synthetic routes to the stereoselective assembly and the elaboration of bioactive compounds |
| Autori: | Autore Email Caso, Maria Federica maria.federica.caso@unina.it |
| Data: | 31 Marzo 2016 |
| Numero di pagine: | 270 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Chimiche |
| Scuola di dottorato: | Scienze chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 28 |
| Coordinatore del Corso di dottorato: | nome email Paduano, Luigi lpaduano@unina.it |
| Tutor: | nome email Iadonisi, Alfonso [non definito] |
| Data: | 31 Marzo 2016 |
| Numero di pagine: | 270 |
| Parole chiave: | Chirality, nucleoside, N-glycosylation, madangamine, iminosugars |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Depositato il: | 11 Apr 2016 17:01 |
| Ultima modifica: | 30 Mag 2017 01:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/10930 |
Abstract
This thesis is focused on the study of the central role of chirality in different kind of molecular structures; in particular, new synthetic pathways have been developed to improve the synthesis of already existing drugs, exploring at the same time the relationship between the chirality and the pharmacological properties of these compounds. Moreover, new enantiomeric systems have been synthetized and their pharmacological properties will be tested to verify the potential bioactivity and use as drugs. The thesis is organized in three major sections focusing on the different molecule typology investigated (nucleosides, iminosugars, alkaloids). The studies on nucleosides and iminosugars have been carried out at the department of Chemical Sciences of University of Naples “Federico II”, while the synthesis of alkaloids has been accomplished at the department of Organic Chemistry of the Faculty of Pharmacy of the University of Barcelona.
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