Caso, Maria Federica (2016) New synthetic routes to the stereoselective assembly and the elaboration of bioactive compounds. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: New synthetic routes to the stereoselective assembly and the elaboration of bioactive compounds
Creators:
CreatorsEmail
Caso, Maria Federicamaria.federica.caso@unina.it
Date: 31 March 2016
Number of Pages: 270
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Chimiche
Scuola di dottorato: Scienze chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 28
Coordinatore del Corso di dottorato:
nomeemail
Paduano, Luigilpaduano@unina.it
Tutor:
nomeemail
Iadonisi, AlfonsoUNSPECIFIED
Date: 31 March 2016
Number of Pages: 270
Uncontrolled Keywords: Chirality, nucleoside, N-glycosylation, madangamine, iminosugars
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 11 Apr 2016 17:01
Last Modified: 30 May 2017 01:00
URI: http://www.fedoa.unina.it/id/eprint/10930

Abstract

This thesis is focused on the study of the central role of chirality in different kind of molecular structures; in particular, new synthetic pathways have been developed to improve the synthesis of already existing drugs, exploring at the same time the relationship between the chirality and the pharmacological properties of these compounds. Moreover, new enantiomeric systems have been synthetized and their pharmacological properties will be tested to verify the potential bioactivity and use as drugs. The thesis is organized in three major sections focusing on the different molecule typology investigated (nucleosides, iminosugars, alkaloids). The studies on nucleosides and iminosugars have been carried out at the department of Chemical Sciences of University of Naples “Federico II”, while the synthesis of alkaloids has been accomplished at the department of Organic Chemistry of the Faculty of Pharmacy of the University of Barcelona.

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