Luchini, Alessandra (2016) Iron Oxide Nanoparticles as MRI Contrast Agents: a Physico-chemical Insight. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Iron Oxide Nanoparticles as MRI Contrast Agents: a Physico-chemical Insight
Date: 31 March 2016
Number of Pages: 130
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Chimiche
Scuola di dottorato: Scienze chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 28
Coordinatore del Corso di dottorato:
D'Errico, GerardinoUNSPECIFIED
Date: 31 March 2016
Number of Pages: 130
Uncontrolled Keywords: SPIONs, MRI contrast agents, inorganic nanoparticles, Dynamic Light Scattering, Small Angle Neutron Scattering, Neutron Reflectivity.
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/02 - Chimica fisica
Date Deposited: 11 Apr 2016 17:02
Last Modified: 20 May 2017 01:00


SuperParamagnetic Iron Oxide Nanoparticles (SPIONs) are effective contrast agents for Magnetic Resonance Imaging. The modification of SPION surface has emerged as imperative to induce stability in aqueous media and biocompatibility. On the grounds of the published literature, we optimized a robust strategy for the preparation of SPION aqueous suspension suitable for biocompatible applications. The functionalization strategy was applied to SPIONs synthesized through thermal-decomposition method, but, in principle, it can also be extended to other inorganic nanoparticles. A detailed description of the preparation protocols adopted for the obtainment of functionalized SPIONs is reported together with a detailed characterization of their structure and composition. As a result, monodispersed functionalized SPIONs with high biocompatibility and effective activity as MRI contrast agents were obtained. Nevertheless, reliable information is often required about the behavior of nanoparticles in biological systems. For this purpose, the interaction between the functionalized SPIONs and lipid bilayers mimicking of the plasma cellular membrane was characterized. Finally, as a further step in the development of functionalized SPIONs for biomedical applications, the versatility of the optimized functionalization strategy was exploited to prepare prototypes of theranostic nanoparticles as well as dualmodal imaging contrast agents.

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