Strisciuglio, Caterina (2016) New insights in the pathogenesis and in the management of Pediatric Inflammatory Bowel Disease. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: New insights in the pathogenesis and in the management of Pediatric Inflammatory Bowel Disease
Creators:
CreatorsEmail
Strisciuglio, Caterinacaterinastrisciuglio@hotmail.it
Date: 31 March 2016
Number of Pages: 254
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Mediche Traslazionali
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Riproduzione, sviluppo ed accrescimento dell'uomo
Ciclo di dottorato: 28
Coordinatore del Corso di dottorato:
nomeemail
Pignata, Claudiopignata@unina.it
Tutor:
nomeemail
Troncone, RiccardoUNSPECIFIED
Date: 31 March 2016
Number of Pages: 254
Uncontrolled Keywords: Pediatric Inflammatory Bowel Disease, Pathogenesis, Therapy
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica
Date Deposited: 13 Apr 2016 07:39
Last Modified: 28 Apr 2017 01:00
URI: http://www.fedoa.unina.it/id/eprint/10992

Abstract

Inflammatory bowel disease (IBD) is a world- wide health-care problem with a continually increasing incidence. The exact cause of IBD is still unknown, but is thought to be due to a combination of patient’s genetics, microbiome, immune response, and the environment that result in an excessive and abnormal immune response against commensal flora in genetically susceptible individuals. Therefore the main aims of my thesis are deepen the knowledge of IBD pathogenesis investigating genetic susceptibility and its functional implication in pediatric inflammatory bowel disease, as well as describing peculiar clinical phenotype. Moreover, I propose new therapeutic strategies for the treatment of the disease. A true understanding of IBD pathogenesis is mandatory to improve current therapeutic approaches to IBD. There is no doubt that there has been an enormous improvement in the management of IBD, however results are far from ideal, particularly in regard to rather predictable recurrence of disease. Since IBD is the result of a complex integration of different components, an effective therapy can only be achieved if an IBD integrated approach is implemented. Hopefully, the collection of large amounts of molecular data from genomic, proteomic, and microbiomic arrays could generate models that could improve patient classifications, predict clinical course, select the most logical treatment forms, and anticipate outcome.

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