Trinchillo, Marina (2016) NOVEL AU(I)-BASED MOLECULAR CATALYSTS: FROM KNOW HOW TO KNOW WHY. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | NOVEL AU(I)-BASED MOLECULAR CATALYSTS: FROM KNOW HOW TO KNOW WHY |
| Autori: | Autore Email Trinchillo, Marina MARINA.TRINCHILLO@UNINA.IT |
| Data: | 31 Marzo 2016 |
| Numero di pagine: | 254 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Chimiche |
| Scuola di dottorato: | Scienze chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 28 |
| Coordinatore del Corso di dottorato: | nome email Paduano, Luigi LPADUANO@UNINA.IT |
| Tutor: | nome email Busico, Vincenzo [non definito] D'Amora, Angela [non definito] |
| Data: | 31 Marzo 2016 |
| Numero di pagine: | 254 |
| Parole chiave: | GOLD CATALYSIS - HOMOGENEOUS CATALYSIS - ALKOXYLATION - ANION EFFECT - NHC COMPOUNDS - FUNCTIONALIZED NHC LIGANDS - ANTIPROLIFERATIVE ACTIVITY |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/03 - Chimica generale e inorganica |
| Depositato il: | 11 Apr 2016 17:03 |
| Ultima modifica: | 20 Mag 2017 01:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/11000 |
Abstract
In recent years, linear gold(I) complexes have been vastly employed in both homogeneous catalysis and medicinal applications, as anticancer agents. In this thesis novel Au(I)-complexes have been synthesized and their catalytic behavior has been deeply studied in the hydroalkoxylation reaction of alkynes, with particular focus on the role of the anion in different steps of the catalytic cycle, obtaining very interesting results. Furthermore, gold(I) compounds were screened for their antiproliferative effects on different cell lines, and in some cases very promising cytotoxic properties were found.
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