Caiazzo, Giuseppina (2017) The role of interleukin-36 in inflammatory skin diseases. [Tesi di dottorato]
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Tesi Dottorato Giuseppina Caiazzo.pdf Download (1MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | The role of interleukin-36 in inflammatory skin diseases |
| Autori: | Autore Email Caiazzo, Giuseppina giuseppina.caiazzo@mail.com |
| Data: | 4 Maggio 2017 |
| Numero di pagine: | 44 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Clinica e Chirurgia |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 29 |
| Coordinatore del Corso di dottorato: | nome email Marone, Gianni marone@unina.it |
| Tutor: | nome email Ayala, Fabio [non definito] |
| Data: | 4 Maggio 2017 |
| Numero di pagine: | 44 |
| Parole chiave: | IL-36 psoriasis skin inflammation |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree |
| Depositato il: | 28 Apr 2017 12:09 |
| Ultima modifica: | 13 Mar 2018 10:27 |
| URI: | http://www.fedoa.unina.it/id/eprint/11457 |
| DOI: | 10.6093/UNINA/FEDOA/11457 |
Abstract
Interleukin (IL)-36 cytokines are new members of the IL-1 family, that include proinflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. IL-36 cytokines are expressed in a specific manner by monocytes/macrophages, dendritic cells (DCs), T cells subsets, keratinocytes, Langerhans cells, and mucosal epithelium. Since IL-36 cytokines are predominantly expressed in keratinocytes it is not surprising that specifically skin disorders have been explored for associations with these cytokines. Several reports have found that IL-36α and IL-36γ are up-regulated in psoriatic and allergic contact dermatitis skin. Over recent years much has been learned on their important functions in the regulation of immune response and, especially, on their involvement in many inflammatory conditions. In this study, we wanted to elucidate the role of these mediators in the pathogenesis of most common inflammatory skin diseases such as, psoriasis, allergic contact dermatitis and polymorphic light eruption.
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