Caiazzo, Giuseppina (2017) The role of interleukin-36 in inflammatory skin diseases. [Tesi di dottorato]

Tesi Dottorato Giuseppina Caiazzo.pdf

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Item Type: Tesi di dottorato
Resource language: English
Title: The role of interleukin-36 in inflammatory skin diseases
Date: 4 May 2017
Number of Pages: 44
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Clinica e Chirurgia
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
Date: 4 May 2017
Number of Pages: 44
Keywords: IL-36 psoriasis skin inflammation
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree
Date Deposited: 28 Apr 2017 12:09
Last Modified: 13 Mar 2018 10:27
DOI: 10.6093/UNINA/FEDOA/11457

Collection description

Interleukin (IL)-36 cytokines are new members of the IL-1 family, that include proinflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. IL-36 cytokines are expressed in a specific manner by monocytes/macrophages, dendritic cells (DCs), T cells subsets, keratinocytes, Langerhans cells, and mucosal epithelium. Since IL-36 cytokines are predominantly expressed in keratinocytes it is not surprising that specifically skin disorders have been explored for associations with these cytokines. Several reports have found that IL-36α and IL-36γ are up-regulated in psoriatic and allergic contact dermatitis skin. Over recent years much has been learned on their important functions in the regulation of immune response and, especially, on their involvement in many inflammatory conditions. In this study, we wanted to elucidate the role of these mediators in the pathogenesis of most common inflammatory skin diseases such as, psoriasis, allergic contact dermatitis and polymorphic light eruption.


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