Ambrosio, Susanna
(2017)
MYC proteins in human cancer: epigenetic changes and molecular targeting.
[Tesi di dottorato]
| Item Type: |
Tesi di dottorato
|
| Resource language: |
English |
| Title: |
MYC proteins in human cancer: epigenetic changes and molecular targeting |
| Creators: |
| Creators | Email |
|---|
| Ambrosio, Susanna | susanna.ambrosio@unina.it |
|
| Date: |
9 April 2017 |
| Number of Pages: |
96 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Biologia |
| Dottorato: |
Biologia |
| Ciclo di dottorato: |
29 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Cozzolino, Salvatore | salvatore.cozzolino@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Majello, Barbara | UNSPECIFIED |
|
| Date: |
9 April 2017 |
| Number of Pages: |
96 |
| Keywords: |
MYC; LSD1; Neuroblastoma |
| Settori scientifico-disciplinari del MIUR: |
Area 05 - Scienze biologiche > BIO/18 - Genetica |
[error in script]
[error in script]
| Date Deposited: |
20 Apr 2017 11:37 |
| Last Modified: |
07 Mar 2018 12:58 |
| URI: |
http://www.fedoa.unina.it/id/eprint/11653 |
Collection description
Oncogenic activation of MYC proteins affects multiple intracellular pathways, culminating in neoplastic transformation in many cell types. MYC overexpression is involved in all aspects of tumor cell biology including proliferation, cell survival, differentiation, angiogenesis and metastasis. Furthermore, cell proliferation, metabolic boost and survival promoted by MYC produce cells with highly unstable genomes, contributing to tumor progression and maintenance. This study expands our knowledge about the impact of MYC oncogenes alterations on damage response and repair networks. Moreover, this study provides evidences that the histone demethylase LSD1 is a critical co-factor of MYCN repressive function in neuroblastoma and exerts a key role in the control of many important aspects of cell biology through the transcriptional regulation of specific target genes, suggesting that LSD1 inhibition may have strong therapeutic relevance to counteract MYCN-driven oncogenesis.
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