Ambrosio, Susanna (2017) MYC proteins in human cancer: epigenetic changes and molecular targeting. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: MYC proteins in human cancer: epigenetic changes and molecular targeting
Creators:
CreatorsEmail
Ambrosio, Susannasusanna.ambrosio@unina.it
Date: 9 April 2017
Number of Pages: 96
Institution: Università degli Studi di Napoli Federico II
Department: Biologia
Dottorato: Biologia
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
nomeemail
Cozzolino, Salvatoresalvatore.cozzolino@unina.it
Tutor:
nomeemail
Majello, BarbaraUNSPECIFIED
Date: 9 April 2017
Number of Pages: 96
Uncontrolled Keywords: MYC; LSD1; Neuroblastoma
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/18 - Genetica
Date Deposited: 20 Apr 2017 11:37
Last Modified: 07 Mar 2018 12:58
URI: http://www.fedoa.unina.it/id/eprint/11653

Abstract

Oncogenic activation of MYC proteins affects multiple intracellular pathways, culminating in neoplastic transformation in many cell types. MYC overexpression is involved in all aspects of tumor cell biology including proliferation, cell survival, differentiation, angiogenesis and metastasis. Furthermore, cell proliferation, metabolic boost and survival promoted by MYC produce cells with highly unstable genomes, contributing to tumor progression and maintenance. This study expands our knowledge about the impact of MYC oncogenes alterations on damage response and repair networks. Moreover, this study provides evidences that the histone demethylase LSD1 is a critical co-factor of MYCN repressive function in neuroblastoma and exerts a key role in the control of many important aspects of cell biology through the transcriptional regulation of specific target genes, suggesting that LSD1 inhibition may have strong therapeutic relevance to counteract MYCN-driven oncogenesis.

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